Correlations between sample morphology and MALDI-TOF MS signal characteristics

A. Feldman; M. Antoine; P. Demirev; J. Lin

Correlations between sample morphology and MALDI-TOF MS signal characteristics

A. Feldman, M. Antoine, P. Demirev, J. Lin

School of Medicine

Research output: Contribution to conference › Paper › peer-review

Abstract

The potential for using quantitative characteristics calculated from digital microscopic images of samples to predict 'hot spots' locations in order to guide MALDI signal acquisition was analyzed. Initial studies of MALDI signal correlations were performed with data obtained on a Kompact MALDI Discovery instrument with one-dimensional (1D) rastering capability. The angiotensin peak area for each trace was estimated and the spatial autocorrelation function of the signal was computed. The results suggest that strategies for performing optimal signal fusion based on visual surface features should be pursued with caution and that 'hot spot' locations for one ion species will not necessarily correspond to those for other ion species.

Original language	English (US)
Pages	35-36
Number of pages	2
State	Published - Dec 1 2002
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: Jun 2 2002 → Jun 6 2002

Other

Other	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	6/2/02 → 6/6/02

ASJC Scopus subject areas

Spectroscopy

Cite this

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title = "Correlations between sample morphology and MALDI-TOF MS signal characteristics",

abstract = "The potential for using quantitative characteristics calculated from digital microscopic images of samples to predict 'hot spots' locations in order to guide MALDI signal acquisition was analyzed. Initial studies of MALDI signal correlations were performed with data obtained on a Kompact MALDI Discovery instrument with one-dimensional (1D) rastering capability. The angiotensin peak area for each trace was estimated and the spatial autocorrelation function of the signal was computed. The results suggest that strategies for performing optimal signal fusion based on visual surface features should be pursued with caution and that 'hot spot' locations for one ion species will not necessarily correspond to those for other ion species.",

author = "A. Feldman and M. Antoine and P. Demirev and J. Lin",

year = "2002",

month = dec,

day = "1",

language = "English (US)",

pages = "35--36",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

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TY - CONF

T1 - Correlations between sample morphology and MALDI-TOF MS signal characteristics

AU - Feldman, A.

AU - Antoine, M.

AU - Demirev, P.

AU - Lin, J.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The potential for using quantitative characteristics calculated from digital microscopic images of samples to predict 'hot spots' locations in order to guide MALDI signal acquisition was analyzed. Initial studies of MALDI signal correlations were performed with data obtained on a Kompact MALDI Discovery instrument with one-dimensional (1D) rastering capability. The angiotensin peak area for each trace was estimated and the spatial autocorrelation function of the signal was computed. The results suggest that strategies for performing optimal signal fusion based on visual surface features should be pursued with caution and that 'hot spot' locations for one ion species will not necessarily correspond to those for other ion species.

AB - The potential for using quantitative characteristics calculated from digital microscopic images of samples to predict 'hot spots' locations in order to guide MALDI signal acquisition was analyzed. Initial studies of MALDI signal correlations were performed with data obtained on a Kompact MALDI Discovery instrument with one-dimensional (1D) rastering capability. The angiotensin peak area for each trace was estimated and the spatial autocorrelation function of the signal was computed. The results suggest that strategies for performing optimal signal fusion based on visual surface features should be pursued with caution and that 'hot spot' locations for one ion species will not necessarily correspond to those for other ion species.

UR - http://www.scopus.com/inward/record.url?scp=2442659139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442659139&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:2442659139

SP - 35

EP - 36

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Correlations between sample morphology and MALDI-TOF MS signal characteristics

Abstract

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ASJC Scopus subject areas

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