Correlation of transconjunctival PO2 with cerebral oxygen delivery during cardiopulmonary resuscitation in dogs

A. D. Guerci; K. Thomas; D. Hess; H. R. Halperin; J. E. Tsitlik; E. Wurmb; D. Eitel

doi:10.1097/00003246-198806000-00010

Correlation of transconjunctival PO₂ with cerebral oxygen delivery during cardiopulmonary resuscitation in dogs

A. D. Guerci, K. Thomas, D. Hess, H. R. Halperin, J. E. Tsitlik, E. Wurmb, D. Eitel

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The relationship between transconjunctival PO₂ (PcjO₂) and cerebral oxygen delivery (ḊO₂) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), ḊO₂, and PcjO₂ readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 ± 11/25 ± 5 (SEM) mm Hg, cerebral perfusion and ḊO₂ fell by 53% and 57%, respectively, while PcjO₂ fell by 87%. After epinephrine administration, carotid pressure increased to 128 ± 13/48 ± 9 mm Hg, and CBF and ḊO₂ rose to 130% and 115% of pre-arrest levels, respectively, but PcjO₂ readings remained at 11% of control values. Thus, PcjO₂ failed to reflect accurately either CBF or ḊO₂ during CPR. In the presence of epinephrine, PcjO₂ does not seem to provide an accurate index of the effectiveness of CPR.

Original language	English (US)
Pages (from-to)	612-614
Number of pages	3
Journal	Critical care medicine
Volume	16
Issue number	6
DOIs	https://doi.org/10.1097/00003246-198806000-00010
State	Published - 1988

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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title = "Correlation of transconjunctival PO2 with cerebral oxygen delivery during cardiopulmonary resuscitation in dogs",

abstract = "The relationship between transconjunctival PO2 (PcjO2) and cerebral oxygen delivery (ḊO2) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), ḊO2, and PcjO2 readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 ± 11/25 ± 5 (SEM) mm Hg, cerebral perfusion and ḊO2 fell by 53% and 57%, respectively, while PcjO2 fell by 87%. After epinephrine administration, carotid pressure increased to 128 ± 13/48 ± 9 mm Hg, and CBF and ḊO2 rose to 130% and 115% of pre-arrest levels, respectively, but PcjO2 readings remained at 11% of control values. Thus, PcjO2 failed to reflect accurately either CBF or ḊO2 during CPR. In the presence of epinephrine, PcjO2 does not seem to provide an accurate index of the effectiveness of CPR.",

author = "Guerci, {A. D.} and K. Thomas and D. Hess and Halperin, {H. R.} and Tsitlik, {J. E.} and E. Wurmb and D. Eitel",

year = "1988",

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T1 - Correlation of transconjunctival PO2 with cerebral oxygen delivery during cardiopulmonary resuscitation in dogs

AU - Guerci, A. D.

AU - Thomas, K.

AU - Hess, D.

AU - Halperin, H. R.

AU - Tsitlik, J. E.

AU - Wurmb, E.

AU - Eitel, D.

PY - 1988

Y1 - 1988

N2 - The relationship between transconjunctival PO2 (PcjO2) and cerebral oxygen delivery (ḊO2) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), ḊO2, and PcjO2 readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 ± 11/25 ± 5 (SEM) mm Hg, cerebral perfusion and ḊO2 fell by 53% and 57%, respectively, while PcjO2 fell by 87%. After epinephrine administration, carotid pressure increased to 128 ± 13/48 ± 9 mm Hg, and CBF and ḊO2 rose to 130% and 115% of pre-arrest levels, respectively, but PcjO2 readings remained at 11% of control values. Thus, PcjO2 failed to reflect accurately either CBF or ḊO2 during CPR. In the presence of epinephrine, PcjO2 does not seem to provide an accurate index of the effectiveness of CPR.

AB - The relationship between transconjunctival PO2 (PcjO2) and cerebral oxygen delivery (ḊO2) was examined in dogs during sinus rhythm and CPR with an inflatable vest. Microsphere-determined cerebral blood flow (CBF), ḊO2, and PcjO2 readings were normal during sinus rhythm. During CPR, with carotid pressure of 82 ± 11/25 ± 5 (SEM) mm Hg, cerebral perfusion and ḊO2 fell by 53% and 57%, respectively, while PcjO2 fell by 87%. After epinephrine administration, carotid pressure increased to 128 ± 13/48 ± 9 mm Hg, and CBF and ḊO2 rose to 130% and 115% of pre-arrest levels, respectively, but PcjO2 readings remained at 11% of control values. Thus, PcjO2 failed to reflect accurately either CBF or ḊO2 during CPR. In the presence of epinephrine, PcjO2 does not seem to provide an accurate index of the effectiveness of CPR.

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JO - Critical care medicine

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Correlation of transconjunctival PO₂ with cerebral oxygen delivery during cardiopulmonary resuscitation in dogs

Abstract

ASJC Scopus subject areas

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