@inproceedings{7ac7bcdbf64a4267884e7c79c4e06483,
title = "Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR",
abstract = "Radiation induced pulmonary diseases can change the tissue material properties of lung parenchyma and the mechanics of the respiratory system. Recent advances in multi-detector-row CT (MDCT), 4DCT respiratory gating methods, and image processing techniques enable us to follow and measure those changes noninvasively during radiation therapy at a regional level. This study compares the 4DCT based ventilation measurement with the results from hyperpolarized helium-3 MR using the cumulative distribution function maps and the relative overlap (RO) statistic. We show that the similarity between the two measurements increases as the increase of the B-Spline grid spacing and Laplacian weighting which result a smoother ventilation map. The best similarity is found with weighting of 0.5 for linear elasticity and B-Spline grid spacing of 32 mm. Future work is to improve the lung image registration algorithm by incorporating hyperpolarized helium-3 MR information so as to improve its physiological modeling of the lung tissue deformation.",
keywords = "4DCT, Image registration, MRI, Pulmonary, Ventilation",
author = "Kai Ding and Kunlin Cao and Wilson Miller and Gary Christensen and Joseph Reinhardt and Stanley Benedict and Bruce Libby and Ke Sheng",
year = "2012",
doi = "10.1117/12.912793",
language = "English (US)",
isbn = "9780819489661",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Medical Imaging 2012",
note = "Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 05-02-2012 Through 07-02-2012",
}