Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study

Tanya Simuni; Chelsea Caspell-Garcia; Christopher Coffey; Lama M. Chahine; Shirley Lasch; Wolfgang H. Oertel; Geert Mayer; Birgit Högl; Ron Postuma; Aleksandar Videnovic; Amy Willis Amara; Ken Marek; David Russell; Stewart Factor; Penelope Hogarth; David Standaert; Robert Hauser; Joseph Jankovic; Matthew Stern; Lama Chahine; James Leverenz; Samuel Frank; Irene Richard; Klaus Seppi; Holly Shill; Hubert Fernandez; Daniela Berg; Isabel Wurster; Douglas Galasko; Zoltan Mari; David Brooks; Nicola Pavese; Paolo Barone; Stuart Isaacson; Alberto Espay; Dominic Rowe; Melanie Brandabur; James Tetrud; Grace Liang; Alex Iranzo; Eduardo Tolosa; Laura Leary; Cheryl Riordan; Linda Rees; Alicia Portillo; Art Lenahan; Karen Williams; Stephanie Guthrie; Ashlee Rawlins; Sherry Harlan; Christine Hunter; Baochan Tran; Abigail Darin; Carly Linder; Marne Baca; Heli Venkov; Cathi Ann Thomas; Raymond James; Cheryl Deeley; Courtney Bishop; Fabienne Sprenger; Diana Willeke; Sanja Obradov; Jennifer Mule; Nancy Monahan; Katharina Gauss; Deborah Fontaine; Christina Gigliotti; McCoy Arita McCoy; Becky Dunlop; Bina Shah; Susan Ainscough; Angela James; Rebecca Silverstein; Kristy Espay; Madelaine Ranola; Claudia Trenkwalder; Alastair D. Reith; Arie Struyk; Bradley Boeve; Brian Harvey; Cindy Comella; David Tattersall; Madeline Kelly; Nancy Foldvary; Chelsea Caspell; Liz Uribe; Eric Foster; Katherine Gloer; Jon Yankey; Karl Kieburtz; Renee Wilson; Alice Rudolph; Cynthia Casaceli; Sherer Todd Sherer; Sohini Chowdhury; Mark Frasier; Catherine Kopil; Vanessa Arnedo; Norbert Schuff; Paola Casalin; Giulia Malferrari; John Trojanowski; Les Shaw; Andrew Singleton; Keith A. Hawkins

doi:10.1002/mds.26248

Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study

Tanya Simuni, Chelsea Caspell-Garcia, Christopher Coffey, Lama M. Chahine, Shirley Lasch, Wolfgang H. Oertel, Geert Mayer, Birgit Högl, Ron Postuma, Aleksandar Videnovic, Amy Willis Amara, Ken Marek, David Russell, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Matthew Stern, Lama ChahineJames Leverenz, Samuel Frank, Irene Richard, Klaus Seppi, Holly Shill, Hubert Fernandez, Daniela Berg, Isabel Wurster, Douglas Galasko, Zoltan Mari, David Brooks, Nicola Pavese, Paolo Barone, Stuart Isaacson, Alberto Espay, Dominic Rowe, Melanie Brandabur, James Tetrud, Grace Liang, Alex Iranzo, Eduardo Tolosa, Laura Leary, Cheryl Riordan, Linda Rees, Alicia Portillo, Art Lenahan, Karen Williams, Stephanie Guthrie, Ashlee Rawlins, Sherry Harlan, Christine Hunter, Baochan Tran, Abigail Darin, Carly Linder, Marne Baca, Heli Venkov, Cathi Ann Thomas, Raymond James, Cheryl Deeley, Courtney Bishop, Fabienne Sprenger, Diana Willeke, Sanja Obradov, Jennifer Mule, Nancy Monahan, Katharina Gauss, Deborah Fontaine, Christina Gigliotti, McCoy Arita McCoy, Becky Dunlop, Bina Shah, Susan Ainscough, Angela James, Rebecca Silverstein, Kristy Espay, Madelaine Ranola, Claudia Trenkwalder, Alastair D. Reith, Arie Struyk, Bradley Boeve, Brian Harvey, Cindy Comella, David Tattersall, Madeline Kelly, Nancy Foldvary, Chelsea Caspell, Liz Uribe, Eric Foster, Katherine Gloer, Jon Yankey, Karl Kieburtz, Renee Wilson, Alice Rudolph, Cynthia Casaceli, Sherer Todd Sherer, Sohini Chowdhury, Mark Frasier, Catherine Kopil, Vanessa Arnedo, Norbert Schuff, Paola Casalin, Giulia Malferrari, John Trojanowski, Les Shaw, Andrew Singleton, Keith A. Hawkins

School of Medicine

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Objective: This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls. Methods: Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10. Results: Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (P=0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (P=0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (P=0.05) but not alpha-synuclein spinal fluid levels in PD. Conclusions: This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.

Original language	English (US)
Pages (from-to)	1371-1381
Number of pages	11
Journal	Movement disorders : official journal of the Movement Disorder Society
Volume	30
Issue number	10
DOIs	https://doi.org/10.1002/mds.26248
State	Published - Sep 1 2015

Keywords

Biomarkers
Daytime somnolence
Parkinson's disease

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1002/mds.26248

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Simuni, T., Caspell-Garcia, C., Coffey, C., Chahine, L. M., Lasch, S., Oertel, W. H., Mayer, G., Högl, B., Postuma, R., Videnovic, A., Amara, A. W., Marek, K., Russell, D., Factor, S., Hogarth, P., Standaert, D., Hauser, R., Jankovic, J., Stern, M., ... Hawkins, K. A. (2015). Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study. Movement disorders : official journal of the Movement Disorder Society, 30(10), 1371-1381. https://doi.org/10.1002/mds.26248

Simuni, T, Caspell-Garcia, C, Coffey, C, Chahine, LM, Lasch, S, Oertel, WH, Mayer, G, Högl, B, Postuma, R, Videnovic, A, Amara, AW, Marek, K, Russell, D, Factor, S, Hogarth, P, Standaert, D, Hauser, R, Jankovic, J, Stern, M, Chahine, L, Leverenz, J, Frank, S, Richard, I, Seppi, K, Shill, H, Fernandez, H, Berg, D, Wurster, I, Galasko, D, Mari, Z, Brooks, D, Pavese, N, Barone, P, Isaacson, S, Espay, A, Rowe, D, Brandabur, M, Tetrud, J, Liang, G, Iranzo, A, Tolosa, E, Leary, L, Riordan, C, Rees, L, Portillo, A, Lenahan, A, Williams, K, Guthrie, S, Rawlins, A, Harlan, S, Hunter, C, Tran, B, Darin, A, Linder, C, Baca, M, Venkov, H, Thomas, CA, James, R, Deeley, C, Bishop, C, Sprenger, F, Willeke, D, Obradov, S, Mule, J, Monahan, N, Gauss, K, Fontaine, D, Gigliotti, C, Arita McCoy, M, Dunlop, B, Shah, B, Ainscough, S, James, A, Silverstein, R, Espay, K, Ranola, M, Trenkwalder, C, Reith, AD, Struyk, A, Boeve, B, Harvey, B, Comella, C, Tattersall, D, Kelly, M, Foldvary, N, Caspell, C, Uribe, L, Foster, E, Gloer, K, Yankey, J, Kieburtz, K, Wilson, R, Rudolph, A, Casaceli, C, Todd Sherer, S, Chowdhury, S, Frasier, M, Kopil, C, Arnedo, V, Schuff, N, Casalin, P, Malferrari, G, Trojanowski, J, Shaw, L, Singleton, A & Hawkins, KA 2015, 'Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study', Movement disorders : official journal of the Movement Disorder Society, vol. 30, no. 10, pp. 1371-1381. https://doi.org/10.1002/mds.26248

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title = "Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study",

abstract = "Objective: This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls. Methods: Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10. Results: Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (P=0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (P=0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (P=0.05) but not alpha-synuclein spinal fluid levels in PD. Conclusions: This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.",

keywords = "Biomarkers, Daytime somnolence, Parkinson's disease",

author = "Tanya Simuni and Chelsea Caspell-Garcia and Christopher Coffey and Chahine, {Lama M.} and Shirley Lasch and Oertel, {Wolfgang H.} and Geert Mayer and Birgit H{\"o}gl and Ron Postuma and Aleksandar Videnovic and Amara, {Amy Willis} and Ken Marek and David Russell and Stewart Factor and Penelope Hogarth and David Standaert and Robert Hauser and Joseph Jankovic and Matthew Stern and Lama Chahine and James Leverenz and Samuel Frank and Irene Richard and Klaus Seppi and Holly Shill and Hubert Fernandez and Daniela Berg and Isabel Wurster and Douglas Galasko and Zoltan Mari and David Brooks and Nicola Pavese and Paolo Barone and Stuart Isaacson and Alberto Espay and Dominic Rowe and Melanie Brandabur and James Tetrud and Grace Liang and Alex Iranzo and Eduardo Tolosa and Laura Leary and Cheryl Riordan and Linda Rees and Alicia Portillo and Art Lenahan and Karen Williams and Stephanie Guthrie and Ashlee Rawlins and Sherry Harlan and Christine Hunter and Baochan Tran and Abigail Darin and Carly Linder and Marne Baca and Heli Venkov and Thomas, {Cathi Ann} and Raymond James and Cheryl Deeley and Courtney Bishop and Fabienne Sprenger and Diana Willeke and Sanja Obradov and Jennifer Mule and Nancy Monahan and Katharina Gauss and Deborah Fontaine and Christina Gigliotti and {Arita McCoy}, McCoy and Becky Dunlop and Bina Shah and Susan Ainscough and Angela James and Rebecca Silverstein and Kristy Espay and Madelaine Ranola and Claudia Trenkwalder and Reith, {Alastair D.} and Arie Struyk and Bradley Boeve and Brian Harvey and Cindy Comella and David Tattersall and Madeline Kelly and Nancy Foldvary and Chelsea Caspell and Liz Uribe and Eric Foster and Katherine Gloer and Jon Yankey and Karl Kieburtz and Renee Wilson and Alice Rudolph and Cynthia Casaceli and {Todd Sherer}, Sherer and Sohini Chowdhury and Mark Frasier and Catherine Kopil and Vanessa Arnedo and Norbert Schuff and Paola Casalin and Giulia Malferrari and John Trojanowski and Les Shaw and Andrew Singleton and Hawkins, {Keith A.}",

year = "2015",

month = sep,

day = "1",

doi = "10.1002/mds.26248",

language = "English (US)",

volume = "30",

pages = "1371--1381",

journal = "Movement disorders : official journal of the Movement Disorder Society",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "10",

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TY - JOUR

T1 - Correlates of excessive daytime sleepiness in de novo Parkinson's disease

T2 - A case control study

AU - Simuni, Tanya

AU - Caspell-Garcia, Chelsea

AU - Coffey, Christopher

AU - Chahine, Lama M.

AU - Lasch, Shirley

AU - Oertel, Wolfgang H.

AU - Mayer, Geert

AU - Högl, Birgit

AU - Postuma, Ron

AU - Videnovic, Aleksandar

AU - Amara, Amy Willis

AU - Marek, Ken

AU - Russell, David

AU - Factor, Stewart

AU - Hogarth, Penelope

AU - Standaert, David

AU - Hauser, Robert

AU - Jankovic, Joseph

AU - Stern, Matthew

AU - Chahine, Lama

AU - Leverenz, James

AU - Frank, Samuel

AU - Richard, Irene

AU - Seppi, Klaus

AU - Shill, Holly

AU - Fernandez, Hubert

AU - Berg, Daniela

AU - Wurster, Isabel

AU - Galasko, Douglas

AU - Mari, Zoltan

AU - Brooks, David

AU - Pavese, Nicola

AU - Barone, Paolo

AU - Isaacson, Stuart

AU - Espay, Alberto

AU - Rowe, Dominic

AU - Brandabur, Melanie

AU - Tetrud, James

AU - Liang, Grace

AU - Iranzo, Alex

AU - Tolosa, Eduardo

AU - Leary, Laura

AU - Riordan, Cheryl

AU - Rees, Linda

AU - Portillo, Alicia

AU - Lenahan, Art

AU - Williams, Karen

AU - Guthrie, Stephanie

AU - Rawlins, Ashlee

AU - Harlan, Sherry

AU - Hunter, Christine

AU - Tran, Baochan

AU - Darin, Abigail

AU - Linder, Carly

AU - Baca, Marne

AU - Venkov, Heli

AU - Thomas, Cathi Ann

AU - James, Raymond

AU - Deeley, Cheryl

AU - Bishop, Courtney

AU - Sprenger, Fabienne

AU - Willeke, Diana

AU - Obradov, Sanja

AU - Mule, Jennifer

AU - Monahan, Nancy

AU - Gauss, Katharina

AU - Fontaine, Deborah

AU - Gigliotti, Christina

AU - Arita McCoy, McCoy

AU - Dunlop, Becky

AU - Shah, Bina

AU - Ainscough, Susan

AU - James, Angela

AU - Silverstein, Rebecca

AU - Espay, Kristy

AU - Ranola, Madelaine

AU - Trenkwalder, Claudia

AU - Reith, Alastair D.

AU - Struyk, Arie

AU - Boeve, Bradley

AU - Harvey, Brian

AU - Comella, Cindy

AU - Tattersall, David

AU - Kelly, Madeline

AU - Foldvary, Nancy

AU - Caspell, Chelsea

AU - Uribe, Liz

AU - Foster, Eric

AU - Gloer, Katherine

AU - Yankey, Jon

AU - Kieburtz, Karl

AU - Wilson, Renee

AU - Rudolph, Alice

AU - Casaceli, Cynthia

AU - Todd Sherer, Sherer

AU - Chowdhury, Sohini

AU - Frasier, Mark

AU - Kopil, Catherine

AU - Arnedo, Vanessa

AU - Schuff, Norbert

AU - Casalin, Paola

AU - Malferrari, Giulia

AU - Trojanowski, John

AU - Shaw, Les

AU - Singleton, Andrew

AU - Hawkins, Keith A.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objective: This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls. Methods: Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10. Results: Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (P=0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (P=0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (P=0.05) but not alpha-synuclein spinal fluid levels in PD. Conclusions: This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.

AB - Objective: This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls. Methods: Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10. Results: Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (P=0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (P=0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (P=0.05) but not alpha-synuclein spinal fluid levels in PD. Conclusions: This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.

KW - Biomarkers

KW - Daytime somnolence

KW - Parkinson's disease

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JO - Movement disorders : official journal of the Movement Disorder Society

JF - Movement disorders : official journal of the Movement Disorder Society

IS - 10

ER -

Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study

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