TY - JOUR
T1 - Correlates of Dapivirine Vaginal Ring Acceptance among Women Participating in an Open Label Extension Trial
AU - Mirembe, Brenda Gati
AU - Cabrera, Maria Valdez
AU - van der Straten, Ariane
AU - Nakalega, Rita
AU - Cobbing, Mandy
AU - Mgodi, Nyaradzo M.
AU - Palanee-Phillips, Thesla
AU - Mayo, Ashley J.
AU - Dadabhai, Sufia
AU - Mansoor, Leila E.
AU - Siva, Samantha
AU - Nair, Gonasagrie
AU - Chinula, Lameck
AU - Akello, Carolyne A.
AU - Nakabiito, Clemensia
AU - Soto-Torres, Lydia E.
AU - Baeten, Jared M.
AU - Brown, Elizabeth R.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/3
Y1 - 2023/3
N2 - MTN-025/HOPE was an open-label trial of the dapivirine vaginal ring conducted in four African countries between 2016 and 2018. Women were first offered one ring monthly (at baseline, months 1 and 2), thereafter, transitioned to a more applicable real-world dispensation schedule, − 3 rings quarterly (at months 3, 6 and 9). Logistic regression analysis was used to assess correlates of ring acceptance at baseline and through follow-up. A total of 1456 women (median age 31 years) enrolled, 1342 (92.2%) accepted the ring at baseline and 1163 (79.9%) accepted the ring(s) at all visits. Changing ring dispensation from a monthly to a quarterly schedule had no negative effect on acceptance. Having a primary partner and him knowing about the ring being offered in HOPE, use of long-acting contraception (implants, injections, IUDs) or sterilization were associated with ring acceptance, along with prior strong intention to use the ring in the future. Efforts should consider these factors when rolling out the ring for HIV prevention.
AB - MTN-025/HOPE was an open-label trial of the dapivirine vaginal ring conducted in four African countries between 2016 and 2018. Women were first offered one ring monthly (at baseline, months 1 and 2), thereafter, transitioned to a more applicable real-world dispensation schedule, − 3 rings quarterly (at months 3, 6 and 9). Logistic regression analysis was used to assess correlates of ring acceptance at baseline and through follow-up. A total of 1456 women (median age 31 years) enrolled, 1342 (92.2%) accepted the ring at baseline and 1163 (79.9%) accepted the ring(s) at all visits. Changing ring dispensation from a monthly to a quarterly schedule had no negative effect on acceptance. Having a primary partner and him knowing about the ring being offered in HOPE, use of long-acting contraception (implants, injections, IUDs) or sterilization were associated with ring acceptance, along with prior strong intention to use the ring in the future. Efforts should consider these factors when rolling out the ring for HIV prevention.
KW - African women
KW - HIV Pre-Exposure Prophylaxis
KW - acceptance
KW - choice
KW - dapivirine vaginal ring
KW - microbicide
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U2 - 10.1007/s10461-022-03841-z
DO - 10.1007/s10461-022-03841-z
M3 - Article
C2 - 36066762
AN - SCOPUS:85138095888
SN - 1090-7165
VL - 27
SP - 1030
EP - 1043
JO - AIDS and behavior
JF - AIDS and behavior
IS - 3
ER -