Correlates of Dapivirine Vaginal Ring Acceptance among Women Participating in an Open Label Extension Trial

Brenda Gati Mirembe, Maria Valdez Cabrera, Ariane van der Straten, Rita Nakalega, Mandy Cobbing, Nyaradzo M. Mgodi, Thesla Palanee-Phillips, Ashley J. Mayo, Sufia Dadabhai, Leila E. Mansoor, Samantha Siva, Gonasagrie Nair, Lameck Chinula, Carolyne A. Akello, Clemensia Nakabiito, Lydia E. Soto-Torres, Jared M. Baeten, Elizabeth R. Brown

Research output: Contribution to journalArticlepeer-review

Abstract

MTN-025/HOPE was an open-label trial of the dapivirine vaginal ring conducted in four African countries between 2016 and 2018. Women were first offered one ring monthly (at baseline, months 1 and 2), thereafter, transitioned to a more applicable real-world dispensation schedule, − 3 rings quarterly (at months 3, 6 and 9). Logistic regression analysis was used to assess correlates of ring acceptance at baseline and through follow-up. A total of 1456 women (median age 31 years) enrolled, 1342 (92.2%) accepted the ring at baseline and 1163 (79.9%) accepted the ring(s) at all visits. Changing ring dispensation from a monthly to a quarterly schedule had no negative effect on acceptance. Having a primary partner and him knowing about the ring being offered in HOPE, use of long-acting contraception (implants, injections, IUDs) or sterilization were associated with ring acceptance, along with prior strong intention to use the ring in the future. Efforts should consider these factors when rolling out the ring for HIV prevention.

Original languageEnglish (US)
Pages (from-to)1030-1043
Number of pages14
JournalAIDS and behavior
Volume27
Issue number3
DOIs
StatePublished - Mar 2023
Externally publishedYes

Keywords

  • African women
  • HIV Pre-Exposure Prophylaxis
  • acceptance
  • choice
  • dapivirine vaginal ring
  • microbicide

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

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