TY - JOUR
T1 - Coronavirus Disease 2019 in Pregnancy and Outcomes among Pregnant Women and Neonates
T2 - A Literature Review
AU - Mark, Elyse G.
AU - McAleese, Samuel
AU - Golden, W. Christopher
AU - Gilmore, Maureen M.
AU - Sick-Samuels, Anna
AU - Curless, Melanie S.
AU - Nogee, Lawrence M.
AU - Milstone, Aaron M.
AU - Johnson, Julia
N1 - Funding Information:
Accepted for publication February 1, 2021 From the *Division of Neonatology, Department of Pediatrics, †Division of Infectious Diseases, Department of Pediatrics, and ‡Department of Hospital Epidemiology and Infection Control, Johns Hopkins Hospital, Baltimore, Maryland. A.S.S. is supported by the National Institutes of Health (KL2TR003099). A.M.M. is supported by the National Institutes of Health (K24AI141580). J.J. is supported by the National Institutes of Health (K23HD100594). The other authors have no conflicts of interest to disclose. E.G.M. and S.M. contributed equally to this work. Address for correspondence: Julia Johnson, MD, PhD, Department of Pediatrics, Division of Neonatology, 1800 Orleans Street, Suite 8534, Baltimore, MD 21287. E-mail: jjohn245@jhmi.edu. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.pidj.com). Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0891-3668/21/4005-0473 DOI: 10.1097/INF.0000000000003102
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Limited data are available about the outcomes of coronavirus disease 2019 (COVID-19) during pregnancy and risk of vertical transmission in exposed neonates. We reviewed studies published February 1, 2020, through August 15, 2020, on outcomes in pregnant women with COVID-19 and neonates with perinatal exposure. Among pregnant women with COVID-19, 181 (11%) required intensive care unit admission and 123 (8%) required mechanical ventilation. There were 22 maternal deaths. Most infections occurred in the third trimester. Among women who delivered, 28% had a preterm birth, and 57% had a Caesarean section. Sixty-one (4%) of 1222 neonates with reported testing had at least 1 positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test. The most common symptom among neonates was respiratory distress (n = 126; 21%). There were 14 neonatal deaths, one of which occurred in a neonate with positive testing. Further study of COVID-19 in pregnant women and neonates, including standardized reporting of outcomes, testing and treatment protocols, is essential to optimize maternal and neonatal care.
AB - Limited data are available about the outcomes of coronavirus disease 2019 (COVID-19) during pregnancy and risk of vertical transmission in exposed neonates. We reviewed studies published February 1, 2020, through August 15, 2020, on outcomes in pregnant women with COVID-19 and neonates with perinatal exposure. Among pregnant women with COVID-19, 181 (11%) required intensive care unit admission and 123 (8%) required mechanical ventilation. There were 22 maternal deaths. Most infections occurred in the third trimester. Among women who delivered, 28% had a preterm birth, and 57% had a Caesarean section. Sixty-one (4%) of 1222 neonates with reported testing had at least 1 positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test. The most common symptom among neonates was respiratory distress (n = 126; 21%). There were 14 neonatal deaths, one of which occurred in a neonate with positive testing. Further study of COVID-19 in pregnant women and neonates, including standardized reporting of outcomes, testing and treatment protocols, is essential to optimize maternal and neonatal care.
KW - coronavirus disease 2019
KW - neonate
KW - pregnancy
KW - severe acute respiratory syndrome coronavirus 2
UR - http://www.scopus.com/inward/record.url?scp=85104366110&partnerID=8YFLogxK
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U2 - 10.1097/INF.0000000000003102
DO - 10.1097/INF.0000000000003102
M3 - Review article
C2 - 33847297
AN - SCOPUS:85104366110
SN - 0891-3668
VL - 40
SP - 473
EP - 478
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 5
ER -