Coronary endothelial function assessment using self-gated cardiac cine MRI and k-t sparse SENSE

Jérôme Yerly, Giulia Ginami, Giovanna Nordio, Andrew J. Coristine, Simone Coppo, Pierre Monney, Matthias Stuber

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: Electrocardiogram (ECG)-gated cine MRI, paired with isometric handgrip exercise, can be used to accurately, reproducibly, and noninvasively measure coronary endothelial function (CEF). Obtaining a reliable ECG signal at higher field strengths, however, can be challenging due to rapid gradient switching and an increased heart rate under stress. To address these limitations, we present a self-gated cardiac cine MRI framework for CEF measurements that operates without ECG signal. Methods: Cross-sectional slices of the right coronary artery (RCA) were acquired using a two-dimensional golden angle radial trajectory. This sampling approach, combined with the k-t sparse SENSE algorithm, allows for the reconstruction of both real-time images for self-gating signal calculations and retrospectively reordered self-gated cine images. CEF measurements were quantitatively compared using both the self-gated and the standard ECG-gated approach. Results: Self-gated cine images with high-quality, temporal, and spatial resolution were reconstructed for 18 healthy volunteers. CEF as measured in self-gated images was in good agreement (R2 = 0.60) with that measured by its standard ECG-gated counterpart. Conclusion: High spatial and temporal resolution cross-sectional cine images of the RCA can be obtained without ECG signal. The coronary vasomotor response to handgrip exercise compares favorably with that obtained with the standard ECG-gated method. Magn Reson Med 76:1443–1454, 2015.

Original languageEnglish (US)
Pages (from-to)1443-1454
Number of pages12
JournalMagnetic resonance in medicine
Issue number5
StatePublished - Nov 1 2016


  • compressed sensing
  • coronary
  • endothelial function
  • golden angle
  • k-t sparse SENSE
  • self-gated cardiac cine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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