Coronary artery stenosis: Detection with contrast-enhanced MR imaging in dogs

Maythem Saeed, Michael F. Wendland, Hajime Sakuma, Jean Francois Geschwind, Nikita Derugin, Friedrich M. Cavagna, Charles B. Higgins

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


PURPOSE: To monitor with fast gradient-echo magnetic resonance (MR) imaging the dynamics of gadolinium benzyloxypropionictetraacetate (gadobenate) dimeglumine on myocardial signal intensity in dogs with critical left circumflex coronary artery stenosis. MATERIALS AND METHODS: Fast gradient-echo MR images were acquired in a short axis of the left ventricle. Two bolus injections of 0.05 mmol/kg gadobenate dimeglumine were administered in the basal state after stenosis and after infusion of 0.5 mg/kg dipyridamole. RESULTS: In the basal state, there was an equivalent increase in signal intensity of normal and hypoperfused myocardium during the first pass. Dipyridamole increased left anterior descending flow (287% ± 36; P < .05) and decreased left circumflex flow (65% ± 14; P < .05). The magnitude of signal intensity increase during the second bolus in the hypoperfused region was less than that of normal myocardium (P < .05). Contrast-enhanced images showed the hypoperfused region as smaller than the postmortem measurement (43.8% ± 3.3; P < .05). CONCLUSION: Contrast-enhanced fast MR imaging in the vasodilated state allows detection of hypoperfused myocardium in the presence of critical coronary stenosis.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
Issue number1
StatePublished - Jul 1995
Externally publishedYes


  • Coronary vessels, MR
  • Coronary vessels, stenosis or obstruction
  • Gadolinium
  • Heart, experimental studies
  • Magnetic resonance (MR), contrast enhancement
  • Myocardium, ischemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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