TY - JOUR
T1 - Coronary angiography and left ventriculography in survivors of transmural and nontransmural myocardial infarction
AU - Schulze, Robert A.
AU - Pitt, Bertram
AU - Griffith, Lawrence S.C.
AU - Ducci, Hector H.
AU - Achuff, Stephen C.
AU - Baird, Michael G.
AU - Humphries, J. O.Neal
N1 - Funding Information:
From the Department of Medicine, Cardiology Division, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland. This study was supported by the Myocardial Infarction Research Unll Contract PH 43 NHLI 167-1444 with the National Institutes of Health and Department of Health, Education and Welfare, and The General Clinical Research Center Division of Research Resources Grant 5 MO1 RR 0072-04. Requests for reprints should be addressed to Dr. J. D’Neal Humphries, Department of Medicine, Cardiology Division, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland 21205. Manuscript accepted March 31, 1977. l Research Fellow, American Heart Association, Maryland Affiliate. Present address: 7216 Balmoral Road, Columbia, South Carolina 29205. + Present address: University Hospital, 1405 E. Ann Street, Ann Arbor, Michigan 48109. t Present address: 313 Park Avenue, Falls Church, Virginia 22046. 5 Research Fellow, Canadian Heart Association. Present address: Dttawa Civic Hosplll. 1053 Carling Avenue, Ottawa, Ontario KIY 4E9.
PY - 1978/1
Y1 - 1978/1
N2 - Recent studies have suggested a similar prognosis for patients with transmural myocardial infarction and nontransmural myocardial infarction despite a smaller infarct size in the latter patients estimated by creatine phosphokinase (CPK). Thirty-one patients with transmural myocardial infarction and 17 patients with nontransmural myocardial infarction as defined by electrocardiographic criteria underwent coronary angiography and left ventriculography from 10 to 24 days after they had an acute myocardial infarction. Forty-three of these 48 patients were asymptomatic following their myocardial infarction. When compared to patients with nontransmural myocardial infarction, those with transmural myocardial infarction had greater peak CPK levels, 1,090 ± 210 versus 290 ± 60 IU (p < 0.01). There was no difference in prevalence of single, double or triple vessel coronary artery disease, mean number of coronary arteries 50 per cent narrowed (2.0 ± 0.2 versus 2.0 ± 0.2), near total or total occlusions, coronary score (Friesinger) (7.9 ± 0.6 versus 8.2 ± 0.7), left ventricular ejection fraction (48 ± 2 versus 53 ± 4), or per cent of akinetic-dyskinetic myocardial segments (66 of 242 [27 per cent] versus 32 of 132 [24 per cent]) between two groups. The similar extent of coronary artery narrowing and degree of left ventricular dysfunction may explain the similar prognosis for patients with transmural myocardial infarction and those with nontransmural myocardial infarction despite differences in enzymatically estimated acute infarct size.
AB - Recent studies have suggested a similar prognosis for patients with transmural myocardial infarction and nontransmural myocardial infarction despite a smaller infarct size in the latter patients estimated by creatine phosphokinase (CPK). Thirty-one patients with transmural myocardial infarction and 17 patients with nontransmural myocardial infarction as defined by electrocardiographic criteria underwent coronary angiography and left ventriculography from 10 to 24 days after they had an acute myocardial infarction. Forty-three of these 48 patients were asymptomatic following their myocardial infarction. When compared to patients with nontransmural myocardial infarction, those with transmural myocardial infarction had greater peak CPK levels, 1,090 ± 210 versus 290 ± 60 IU (p < 0.01). There was no difference in prevalence of single, double or triple vessel coronary artery disease, mean number of coronary arteries 50 per cent narrowed (2.0 ± 0.2 versus 2.0 ± 0.2), near total or total occlusions, coronary score (Friesinger) (7.9 ± 0.6 versus 8.2 ± 0.7), left ventricular ejection fraction (48 ± 2 versus 53 ± 4), or per cent of akinetic-dyskinetic myocardial segments (66 of 242 [27 per cent] versus 32 of 132 [24 per cent]) between two groups. The similar extent of coronary artery narrowing and degree of left ventricular dysfunction may explain the similar prognosis for patients with transmural myocardial infarction and those with nontransmural myocardial infarction despite differences in enzymatically estimated acute infarct size.
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U2 - 10.1016/0002-9343(78)90185-7
DO - 10.1016/0002-9343(78)90185-7
M3 - Article
C2 - 623126
AN - SCOPUS:0017872935
SN - 0002-9343
VL - 64
SP - 108
EP - 113
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 1
ER -