Corneoscleral xanthogranuloma treated with chemotherapy: The room for nonsurgical management

Osama M. Mustafa, Yassine J. Daoud

Research output: Contribution to journalArticlepeer-review


Purpose: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. Methods: Interventional case report and literature search. Results: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. Conclusion: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.

Original languageEnglish (US)
Pages (from-to)NP23-NP26
JournalEuropean journal of ophthalmology
Issue number2
StatePublished - Mar 1 2020


  • Azathioprine
  • corneoscleral
  • juvenile xanthogranuloma
  • limbal
  • methotrexate
  • xanthoma disseminatum

ASJC Scopus subject areas

  • Ophthalmology


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