Corneal wound healing: holographic stress-test analysis

J. L. Calkins, B. F. Hochheimer, W. J. Stark

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Double-exposure holograms are taken of the patient's cornea after a heartbeat. The resulting stress test, or holographic interferogram, shows sharply demarcated fringe patterns outlining structurally weak areas in the cornea. Wound strength in postoperative keratoplasties is now being evaluated on a routine basis to determine the effect of topical modifications and surgical techniques. All grafts measured to date reveal 'bulging' or weakness of the wound margin by holography even though clinically they are fully 'healed'. Only one patient had a vascularized region of the wound that was stronger than surrounding cornea. It is no longer necessary to resort to pulling the wound apart in animals for measurement of tensile strength.

Original languageEnglish (US)
Pages (from-to)322-334
Number of pages13
JournalInvestigative Ophthalmology and Visual Science
Issue number2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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