Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

Gavin Li; Meghan Berkenstock; Uri Soiberman

doi:10.1016/j.ajoc.2020.100848

Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

Gavin Li, Meghan Berkenstock, Uri Soiberman

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. Observations: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab. Conclusion and importance: Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.

Original language	English (US)
Article number	100848
Journal	American Journal of Ophthalmology Case Reports
Volume	19
DOIs	https://doi.org/10.1016/j.ajoc.2020.100848
State	Published - Sep 2020

Keywords

Atopic dermatitis
Conjunctivitis
Corneal ulceration
Dupilumab

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.ajoc.2020.100848

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title = "Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis",

abstract = "Purpose: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. Observations: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab. Conclusion and importance: Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.",

keywords = "Atopic dermatitis, Conjunctivitis, Corneal ulceration, Dupilumab",

author = "Gavin Li and Meghan Berkenstock and Uri Soiberman",

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year = "2020",

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doi = "10.1016/j.ajoc.2020.100848",

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AU - Berkenstock, Meghan

AU - Soiberman, Uri

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N2 - Purpose: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. Observations: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab. Conclusion and importance: Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.

AB - Purpose: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. Observations: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab. Conclusion and importance: Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.

KW - Atopic dermatitis

KW - Conjunctivitis

KW - Corneal ulceration

KW - Dupilumab

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Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

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