Corneal endothelial function and structure following cryo-injury in the rabbit

J. S. Minkowski, S. P. Bartels, F. C. Delori, S. R. Lee, K. R. Kenyon, A. H. Neufeld

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Wide-field specular microscopy, fluorophotometry, pachymetry, and scanning electron microscopy are used to characterize a reproducible, in vivo model of corneal endothelial injury and recovery in the rabbit. Following an 8-mm central cryo-injury, the cornea remains thickened for as long as 3 weeks. Mean endothelial permeability to fluorescein is above normal for 10 days following injury, but by 14 days postinjury the endothelial permeability to fluorescein is not statistically significantly different from preinjury control values, thus indicating that endothelial permeability probably returns to normal by approximately 2 weeks postinjury. Cell morphology, as determined by scanning electron microscopy, is also essentially normal by 2 weeks postinjury. Endothelial permeability appears to recover before stromal thickness normalizes, suggesting a lag in recovery of endothelial pump function.

Original languageEnglish (US)
Pages (from-to)1416-1425
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Issue number12
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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