Corneal endothelial cytotoxicity of the calotropis procera (ushaar) plant

Hani S. Al-Mezaine; Mohammed A. Al-Amry; Abdullah Al-Assiri; Talal S. Fadel; Khalid F. Tabbara; Ali A. Al-Rajhi

doi:10.1097/ICO.0b013e3181611c34

Corneal endothelial cytotoxicity of the calotropis procera (ushaar) plant

Hani S. Al-Mezaine, Mohammed A. Al-Amry, Abdullah Al-Assiri, Talal S. Fadel, Khalid F. Tabbara, Ali A. Al-Rajhi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

PURPOSE: To report 6 eyes of 5 patients with transient corneal edema after exposure to the milky latex of Calotropis procera (ushaar). METHODS: Interventional case series. RESULTS: Intracorneal penetration of ushaar latex can lead to permanent endothelial cell loss with morphologic alteration. Corneal edema resolved completely in ∼2 weeks in all cases, despite reduced endothelial cell count and abnormal morphology. CONCLUSIONS: Corneal endothelial toxicity of ushaar latex is caused by its ability to penetrate the corneal stroma and induce permanent loss of endothelial cells. Corneal edema resolves if sufficient endothelial cell viability is still present after resolution of ushaar keratitis.

Original language	English (US)
Pages (from-to)	504-506
Number of pages	3
Journal	Cornea
Volume	27
Issue number	4
DOIs	https://doi.org/10.1097/ICO.0b013e3181611c34
State	Published - May 2008
Externally published	Yes

Keywords

Calotropis procera
Corneal edema
Corneal endothelium
Corneal toxicity
Milkweed
Ushaar

ASJC Scopus subject areas

Ophthalmology

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10.1097/ICO.0b013e3181611c34

Cite this

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title = "Corneal endothelial cytotoxicity of the calotropis procera (ushaar) plant",

abstract = "PURPOSE: To report 6 eyes of 5 patients with transient corneal edema after exposure to the milky latex of Calotropis procera (ushaar). METHODS: Interventional case series. RESULTS: Intracorneal penetration of ushaar latex can lead to permanent endothelial cell loss with morphologic alteration. Corneal edema resolved completely in ∼2 weeks in all cases, despite reduced endothelial cell count and abnormal morphology. CONCLUSIONS: Corneal endothelial toxicity of ushaar latex is caused by its ability to penetrate the corneal stroma and induce permanent loss of endothelial cells. Corneal edema resolves if sufficient endothelial cell viability is still present after resolution of ushaar keratitis.",

keywords = "Calotropis procera, Corneal edema, Corneal endothelium, Corneal toxicity, Milkweed, Ushaar",

author = "Al-Mezaine, {Hani S.} and Al-Amry, {Mohammed A.} and Abdullah Al-Assiri and Fadel, {Talal S.} and Tabbara, {Khalid F.} and Al-Rajhi, {Ali A.}",

year = "2008",

month = may,

doi = "10.1097/ICO.0b013e3181611c34",

language = "English (US)",

volume = "27",

pages = "504--506",

journal = "Cornea",

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publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Corneal endothelial cytotoxicity of the calotropis procera (ushaar) plant

AU - Al-Mezaine, Hani S.

AU - Al-Amry, Mohammed A.

AU - Al-Assiri, Abdullah

AU - Fadel, Talal S.

AU - Tabbara, Khalid F.

AU - Al-Rajhi, Ali A.

PY - 2008/5

Y1 - 2008/5

N2 - PURPOSE: To report 6 eyes of 5 patients with transient corneal edema after exposure to the milky latex of Calotropis procera (ushaar). METHODS: Interventional case series. RESULTS: Intracorneal penetration of ushaar latex can lead to permanent endothelial cell loss with morphologic alteration. Corneal edema resolved completely in ∼2 weeks in all cases, despite reduced endothelial cell count and abnormal morphology. CONCLUSIONS: Corneal endothelial toxicity of ushaar latex is caused by its ability to penetrate the corneal stroma and induce permanent loss of endothelial cells. Corneal edema resolves if sufficient endothelial cell viability is still present after resolution of ushaar keratitis.

AB - PURPOSE: To report 6 eyes of 5 patients with transient corneal edema after exposure to the milky latex of Calotropis procera (ushaar). METHODS: Interventional case series. RESULTS: Intracorneal penetration of ushaar latex can lead to permanent endothelial cell loss with morphologic alteration. Corneal edema resolved completely in ∼2 weeks in all cases, despite reduced endothelial cell count and abnormal morphology. CONCLUSIONS: Corneal endothelial toxicity of ushaar latex is caused by its ability to penetrate the corneal stroma and induce permanent loss of endothelial cells. Corneal edema resolves if sufficient endothelial cell viability is still present after resolution of ushaar keratitis.

KW - Calotropis procera

KW - Corneal edema

KW - Corneal endothelium

KW - Corneal toxicity

KW - Milkweed

KW - Ushaar

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SN - 0277-3740

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JO - Cornea

JF - Cornea

IS - 4

ER -

Corneal endothelial cytotoxicity of the calotropis procera (ushaar) plant

Abstract

Keywords

ASJC Scopus subject areas

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