TY - JOUR
T1 - Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk
T2 - A Prospective Birth Cohort Study
AU - Raghavan, Ramkripa
AU - Fallin, M. Daniele
AU - Hong, Xiumei
AU - Wang, Guoying
AU - Ji, Yuelong
AU - Stuart, Elizabeth A.
AU - Paige, David
AU - Wang, Xiaobin
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.
AB - Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.
KW - Adiponectin
KW - Autism
KW - Cytokines
KW - Preterm birth
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U2 - 10.1007/s10803-018-3688-5
DO - 10.1007/s10803-018-3688-5
M3 - Article
C2 - 30043356
AN - SCOPUS:85050613149
SN - 0162-3257
VL - 49
SP - 173
EP - 184
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 1
ER -