TY - JOUR
T1 - Cooking with liquefied petroleum gas or biomass and fetal growth outcomes
T2 - a multi-country randomised controlled trial
AU - Household Air Pollution Intervention Network (HAPIN) Investigators
AU - Checkley, William
AU - Thompson, Lisa M.
AU - Hossen, Shakir
AU - Nicolaou, Laura
AU - Williams, Kendra N.
AU - Hartinger, Stella M.
AU - Chiang, Marilu
AU - Balakrishnan, Kalpana
AU - Garg, Sarada S.
AU - Thangavel, Gurusamy
AU - Aravindalochanan, Vigneswari
AU - Rosa, Ghislaine
AU - Mukeshimana, Alexie
AU - Ndagijimana, Florien
AU - McCracken, John P.
AU - Diaz-Artiga, Anaité
AU - Sinharoy, Sheela S.
AU - Waller, Lance
AU - Wang, Jiantong
AU - Jabbarzadeh, Shirin
AU - Chen, Yunyun
AU - Steenland, Kyle
AU - Kirby, Miles A.
AU - Ramakrishnan, Usha
AU - Johnson, Michael
AU - Pillarisetti, Ajay
AU - McCollum, Eric D.
AU - Craik, Rachel
AU - Ohuma, Eric O.
AU - Dávila-Román, Victor G.
AU - de las Fuentes, Lisa
AU - Simkovich, Suzanne M.
AU - Peel, Jennifer L.
AU - Clasen, Thomas F.
AU - Papageorghiou, Aris T.
AU - Bankundiye, Gloriose
AU - Boyd Barr, Dana
AU - Burrowes, Vanessa
AU - Bussalleu, Alejandra
AU - Campbell, Devan
AU - Canuz, Eduardo
AU - Castañaza, Adly
AU - Clark, Maggie
AU - Crocker, Mary
AU - De León, Oscar
AU - Dusabimana, Ephrem
AU - Elon, Lisa
AU - Espinoza, Juan G.
AU - Pineda Fuentes, Irma
AU - Ghosh, Ahana
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
PY - 2024/5
Y1 - 2024/5
N2 - Background: Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth. Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda. Pregnant women aged 18–34 years (9–19 weeks of gestation) were randomly assigned in a 1:1 ratio to receive an LPG stove, continuous fuel delivery, and behavioural messaging or to continue usual cooking with biomass for 18 months. We conducted ultrasound assessments at baseline, 24–28 weeks of gestation (the first pregnancy visit), and 32–36 weeks of gestation (the second pregnancy visit), to measure fetal size; we monitored 24 h personal exposures to household air pollutants during these visits; and we weighed children at birth. We conducted intention-to-treat analyses to estimate differences in fetal size between the intervention and control group, and exposure–response analyses to identify associations between household air pollutants and fetal size. This trial is registered with ClinicalTrials.gov (NCT02944682). Findings: Between May 7, 2018, and Feb 29, 2020, we randomly assigned 3200 pregnant women (1593 to the intervention group and 1607 to the control group). The mean gestational age was 14·5 (SD 3·0) weeks and mean maternal age was 25·6 (4·5) years. We obtained ultrasound assessments in 3147 (98·3%) women at baseline, 3052 (95·4%) women at the first pregnancy visit, and 2962 (92·6%) at the second pregnancy visit, through to Aug 25, 2020. Intervention adherence was high (the median proportion of days with biomass stove use was 0·0%, IQR 0·0–1·6) and pregnant women in the intervention group had lower mean exposures to particulate matter with a diameter less than 2·5 μm (PM2·5; 35·0 [SD 37·2] μg/m3 vs 103·3 [97·9] μg/m3) than did women in the control group. We did not find differences in averaged post-randomisation Z scores for head circumference (0·30 vs 0·39; p=0·04), abdominal circumference (0·38 vs 0·39; p=0·99), femur length (0·44 vs 0·45; p=0·73), and estimated fetal weight or birthweight (–0·13 vs –0·12; p=0·70) between the intervention and control groups. Personal exposures to household air pollutants were not associated with fetal size. Interpretation: Although an LPG cooking intervention successfully reduced personal exposure to air pollution during pregnancy, it did not affect fetal size. Our findings do not support the use of unvented liquefied petroleum gas stoves as a strategy to increase fetal growth in settings were biomass fuels are used predominantly for cooking. Funding: US National Institutes of Health and Bill & Melinda Gates Foundation. Translations: For the Kinyarwanda, Spanish and Tamil translations of the abstract see Supplementary Materials section.
AB - Background: Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth. Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda. Pregnant women aged 18–34 years (9–19 weeks of gestation) were randomly assigned in a 1:1 ratio to receive an LPG stove, continuous fuel delivery, and behavioural messaging or to continue usual cooking with biomass for 18 months. We conducted ultrasound assessments at baseline, 24–28 weeks of gestation (the first pregnancy visit), and 32–36 weeks of gestation (the second pregnancy visit), to measure fetal size; we monitored 24 h personal exposures to household air pollutants during these visits; and we weighed children at birth. We conducted intention-to-treat analyses to estimate differences in fetal size between the intervention and control group, and exposure–response analyses to identify associations between household air pollutants and fetal size. This trial is registered with ClinicalTrials.gov (NCT02944682). Findings: Between May 7, 2018, and Feb 29, 2020, we randomly assigned 3200 pregnant women (1593 to the intervention group and 1607 to the control group). The mean gestational age was 14·5 (SD 3·0) weeks and mean maternal age was 25·6 (4·5) years. We obtained ultrasound assessments in 3147 (98·3%) women at baseline, 3052 (95·4%) women at the first pregnancy visit, and 2962 (92·6%) at the second pregnancy visit, through to Aug 25, 2020. Intervention adherence was high (the median proportion of days with biomass stove use was 0·0%, IQR 0·0–1·6) and pregnant women in the intervention group had lower mean exposures to particulate matter with a diameter less than 2·5 μm (PM2·5; 35·0 [SD 37·2] μg/m3 vs 103·3 [97·9] μg/m3) than did women in the control group. We did not find differences in averaged post-randomisation Z scores for head circumference (0·30 vs 0·39; p=0·04), abdominal circumference (0·38 vs 0·39; p=0·99), femur length (0·44 vs 0·45; p=0·73), and estimated fetal weight or birthweight (–0·13 vs –0·12; p=0·70) between the intervention and control groups. Personal exposures to household air pollutants were not associated with fetal size. Interpretation: Although an LPG cooking intervention successfully reduced personal exposure to air pollution during pregnancy, it did not affect fetal size. Our findings do not support the use of unvented liquefied petroleum gas stoves as a strategy to increase fetal growth in settings were biomass fuels are used predominantly for cooking. Funding: US National Institutes of Health and Bill & Melinda Gates Foundation. Translations: For the Kinyarwanda, Spanish and Tamil translations of the abstract see Supplementary Materials section.
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U2 - 10.1016/S2214-109X(24)00033-0
DO - 10.1016/S2214-109X(24)00033-0
M3 - Article
C2 - 38614630
AN - SCOPUS:85189978328
SN - 2214-109X
VL - 12
SP - e815-e825
JO - The Lancet Global Health
JF - The Lancet Global Health
IS - 5
ER -