Conversion of Serotonin (5-Hydroxytryptamine) to 5-Hydroxyindoleacetic Acid by Rabbit Blood

T. Phillip Waalkes, Harriette Coburn

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Free serotonin, in the presence of rabbit whole blood, is oxidized to 5-HIAA. The latter was identified by paper chromatography and by its fluorescence characteristics. Platelets or plasma do not produce the reaction. Evidence is presented that red blood cells, or possibly the white cells, are factors in the conversion of serotonin to 5-HIAA.

Original languageEnglish (US)
Pages (from-to)742-746
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Dec 1958

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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