Conversion from high-dose full-opioid agonists to sublingual buprenorphine reduces pain scores and improves quality of life for chronic pain patients

Danielle Daitch; Jonathan Daitch; Daniel Novinson; Michael Frey; Carol Mitnick; Joseph Pergolizzi

doi:10.1111/pme.12520

Conversion from high-dose full-opioid agonists to sublingual buprenorphine reduces pain scores and improves quality of life for chronic pain patients

Danielle Daitch, Jonathan Daitch, Daniel Novinson, Michael Frey, Carol Mitnick, Joseph Pergolizzi

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objective: This study aims to determine the effectiveness of converting patients from high doses of full-opioid agonists to sublingual (SL) buprenorphine. Design: An observational report of outcomes assessment. Setting: An interventional pain management practice setting in the United States. Subjects: Thirty-five chronic pain patients (age 24-66) were previously treated with high-dose opioid-agonist drugs and converted to SL buprenorphine. Patients' daily morphine equivalents ranged from 200mg to 1,370mg preconversion, with a mean daily dose of 550mg. Methods: A retrospective chart analysis examined numerical pain levels and quality of life scores before and 2 months after conversion to SL buprenorphine. Results: After continuation of SL buprenorphine therapy for 2 months, the mean pain score decreased from 7.2 to 3.5 (P

Original language	English (US)
Pages (from-to)	2087-2094
Number of pages	8
Journal	Pain Medicine
Volume	15
Issue number	12
DOIs	https://doi.org/10.1111/pme.12520
State	Published - Dec 1 2014

Keywords

Analgesia
Buprenorphine
Opioid conversion
Opioid tolerance
Opioid-iNDUCED hYperalgesia
Sublingual buprenorphine

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine
Medicine(all)

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10.1111/pme.12520

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title = "Conversion from high-dose full-opioid agonists to sublingual buprenorphine reduces pain scores and improves quality of life for chronic pain patients",

abstract = "Objective: This study aims to determine the effectiveness of converting patients from high doses of full-opioid agonists to sublingual (SL) buprenorphine. Design: An observational report of outcomes assessment. Setting: An interventional pain management practice setting in the United States. Subjects: Thirty-five chronic pain patients (age 24-66) were previously treated with high-dose opioid-agonist drugs and converted to SL buprenorphine. Patients' daily morphine equivalents ranged from 200mg to 1,370mg preconversion, with a mean daily dose of 550mg. Methods: A retrospective chart analysis examined numerical pain levels and quality of life scores before and 2 months after conversion to SL buprenorphine. Results: After continuation of SL buprenorphine therapy for 2 months, the mean pain score decreased from 7.2 to 3.5 (P",

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AU - Novinson, Daniel

AU - Frey, Michael

AU - Mitnick, Carol

AU - Pergolizzi, Joseph

PY - 2014/12/1

Y1 - 2014/12/1

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KW - Buprenorphine

KW - Opioid conversion

KW - Opioid tolerance

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Conversion from high-dose full-opioid agonists to sublingual buprenorphine reduces pain scores and improves quality of life for chronic pain patients

Abstract

Keywords

ASJC Scopus subject areas

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