Conventional Chondrosarcoma with Clear Cell Features in the Rib: Report of Two Cases and Review of the Literature

Sintawat Wangsiricharoen, Hulai Jalloh, Aaron W. James, Edward F. McCarthy, Carol D. Morris, John M. Gross

Research output: Contribution to journalArticlepeer-review

Abstract

A subset of clear cell chondrosarcomas may contain focal areas of low-grade conventional chondrosarcoma; however, it is rare to find foci resembling clear cell chondrosarcoma admixed with areas otherwise typical conventional chondrosarcoma. We report two patients with conventional chondrosarcoma with clear cell features occurring in the rib, one in the setting of multiple hereditary exostoses (MHE) and the other without MHE. Both patients were found to have a destructive rib mass with a soft tissue component and underwent en bloc resection. Histologic examination revealed predominantly grade 2 conventional chondrosarcomas; however, multiple foci containing large cells with pale eosinophilic to clear cytoplasm, distinct cell borders, centrally located nuclei, and conspicuous nucleoli, resembling clear cell chondrosarcoma were identified throughout the specimen. The significance of clear cell features in an otherwise typical conventional chondrosarcoma, to our knowledge, is unknown and deserves recognition. Finally, these tumors highlight the need for careful histologic examination and proper classification as unexpected findings may impact management.

Original languageEnglish (US)
Pages (from-to)621-626
Number of pages6
JournalInternational journal of surgical pathology
Volume31
Issue number5
DOIs
StatePublished - Aug 2023

Keywords

  • clear cell chondrosarcoma
  • conventional chondrosarcoma
  • conventional chondrosarcoma with clear cell features
  • rib chondrosarcoma

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine

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