TY - JOUR
T1 - Conventional Chondrosarcoma with Clear Cell Features in the Rib
T2 - Report of Two Cases and Review of the Literature
AU - Wangsiricharoen, Sintawat
AU - Jalloh, Hulai
AU - James, Aaron W.
AU - McCarthy, Edward F.
AU - Morris, Carol D.
AU - Gross, John M.
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2023/8
Y1 - 2023/8
N2 - A subset of clear cell chondrosarcomas may contain focal areas of low-grade conventional chondrosarcoma; however, it is rare to find foci resembling clear cell chondrosarcoma admixed with areas otherwise typical conventional chondrosarcoma. We report two patients with conventional chondrosarcoma with clear cell features occurring in the rib, one in the setting of multiple hereditary exostoses (MHE) and the other without MHE. Both patients were found to have a destructive rib mass with a soft tissue component and underwent en bloc resection. Histologic examination revealed predominantly grade 2 conventional chondrosarcomas; however, multiple foci containing large cells with pale eosinophilic to clear cytoplasm, distinct cell borders, centrally located nuclei, and conspicuous nucleoli, resembling clear cell chondrosarcoma were identified throughout the specimen. The significance of clear cell features in an otherwise typical conventional chondrosarcoma, to our knowledge, is unknown and deserves recognition. Finally, these tumors highlight the need for careful histologic examination and proper classification as unexpected findings may impact management.
AB - A subset of clear cell chondrosarcomas may contain focal areas of low-grade conventional chondrosarcoma; however, it is rare to find foci resembling clear cell chondrosarcoma admixed with areas otherwise typical conventional chondrosarcoma. We report two patients with conventional chondrosarcoma with clear cell features occurring in the rib, one in the setting of multiple hereditary exostoses (MHE) and the other without MHE. Both patients were found to have a destructive rib mass with a soft tissue component and underwent en bloc resection. Histologic examination revealed predominantly grade 2 conventional chondrosarcomas; however, multiple foci containing large cells with pale eosinophilic to clear cytoplasm, distinct cell borders, centrally located nuclei, and conspicuous nucleoli, resembling clear cell chondrosarcoma were identified throughout the specimen. The significance of clear cell features in an otherwise typical conventional chondrosarcoma, to our knowledge, is unknown and deserves recognition. Finally, these tumors highlight the need for careful histologic examination and proper classification as unexpected findings may impact management.
KW - clear cell chondrosarcoma
KW - conventional chondrosarcoma
KW - conventional chondrosarcoma with clear cell features
KW - rib chondrosarcoma
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U2 - 10.1177/10668969221113488
DO - 10.1177/10668969221113488
M3 - Article
C2 - 35899291
AN - SCOPUS:85135124188
SN - 1066-8969
VL - 31
SP - 621
EP - 626
JO - International journal of surgical pathology
JF - International journal of surgical pathology
IS - 5
ER -