Controlling Inflammation Improves Aging Skeletal Muscle Health

William A. Fountain; Masatoshi Naruse; Alex Claiborne; Scott Trappe; Todd A. Trappe

doi:10.1249/JES.0000000000000313

Controlling Inflammation Improves Aging Skeletal Muscle Health

William A. Fountain, Masatoshi Naruse, Alex Claiborne, Scott Trappe, Todd A. Trappe

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic inflammation is associated with a decline in aging skeletal muscle health. Inflammation also seems to interfere with the beneficial skeletal muscle adaptations conferred by exercise training in older individuals. We hypothesize that the cyclooxygenase pathway is partially responsible for this negative inflammatory influence on aging skeletal muscle health and plasticity.

Original language	English (US)
Pages (from-to)	51-56
Number of pages	6
Journal	Exercise and Sport Sciences Reviews
Volume	51
Issue number	2
DOIs	https://doi.org/10.1249/JES.0000000000000313
State	Published - Apr 1 2023
Externally published	Yes

Keywords

aging
cyclooxygenase
exercise
inflammaging
inflammation
prostaglandin
skeletal muscle

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000313

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abstract = "Chronic inflammation is associated with a decline in aging skeletal muscle health. Inflammation also seems to interfere with the beneficial skeletal muscle adaptations conferred by exercise training in older individuals. We hypothesize that the cyclooxygenase pathway is partially responsible for this negative inflammatory influence on aging skeletal muscle health and plasticity.",

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author = "Fountain, {William A.} and Masatoshi Naruse and Alex Claiborne and Scott Trappe and Trappe, {Todd A.}",

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AU - Naruse, Masatoshi

AU - Claiborne, Alex

AU - Trappe, Scott

AU - Trappe, Todd A.

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - Chronic inflammation is associated with a decline in aging skeletal muscle health. Inflammation also seems to interfere with the beneficial skeletal muscle adaptations conferred by exercise training in older individuals. We hypothesize that the cyclooxygenase pathway is partially responsible for this negative inflammatory influence on aging skeletal muscle health and plasticity.

AB - Chronic inflammation is associated with a decline in aging skeletal muscle health. Inflammation also seems to interfere with the beneficial skeletal muscle adaptations conferred by exercise training in older individuals. We hypothesize that the cyclooxygenase pathway is partially responsible for this negative inflammatory influence on aging skeletal muscle health and plasticity.

KW - aging

KW - cyclooxygenase

KW - exercise

KW - inflammaging

KW - inflammation

KW - prostaglandin

KW - skeletal muscle

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Controlling Inflammation Improves Aging Skeletal Muscle Health

Abstract

Keywords

ASJC Scopus subject areas

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