Controlling arachidonic acid metabolic network: From single-to multi-target inhibitors of key enzymes

Ying Liu, Zheng Chen, Er Chang Shang, Kun Yang, Deng Guo Wei, Lu Zhou, Xiao Lu Jiang, Chong He, Lu Hua Lai

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Inflammatory diseases are common medical conditions seen in disorders of human immune system. There is a great demand for anti-inflammatory drugs. There are major inflammatory mediators in arachidonic acid metabolic network. Several enzymes in this network have been used as key targets for the development of anti-inflammatory drugs. However, specific single-target inhibitors can not sufficiently control network balance and may cause side effects at the same time. Most inflammation induced diseases come from the complicated coupling of inflammatory cascades involving multiple targets. In order to treat these complicated diseases, drugs that can intervene multi-targets at the same time attracted much attention. The goal of this review is mainly focused on the key enzymes in arachidonic acid metabolic network, such as phospholipase A2, cyclooxygenase, 5-lipoxygenase and eukothene A4 hydrolase. Advance in single target and multi-targe inhibitors is summarized.

Original languageEnglish (US)
Pages (from-to)231-241
Number of pages11
JournalYaoxue Xuebao
Issue number3
StatePublished - Mar 2009
Externally publishedYes


  • Arachidonic acid metabolic network
  • Key enzymes
  • Multi-target inhibitors
  • Single-target inhibitors

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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