@article{914f99940afd4205a0b747e13139276c,
title = "Controlled Comparison of Tetracycline and Furazolidone in Cholera",
abstract = "A controlled comparison of furazolidone and tetracycline in the treatment of cholera indicates that, in either dosage used, furazolidone reduced total stool volume by 50% and duration of diarrhoea by 40%. These results are comparable to those achieved with tetracycline, which was given in presently recommended dosage. Both furazolidone and tetracycline significantly reduced the rate of stool output within 18 to 24 hours of starting antibiotic treatment. Furazolidone was significantly less effective than tetracycline in rapidly and consistently terminating vibrio excretion. One convalescent carrier of cholera vibrios was identified among control patients; none was identified among patients treated with either tetracycline or furazolidone. All Vibrio cholerae strains tested were sensitive to tetracycline and furazolidone, but larger concentrations of the latter were required to achieve inhibition of growth. It is concluded that tetracycline remains the antibiotic of choice in cholera but that furazolidone would be a useful adjunct to cholera therapy when tetracycline is unobtainable or if strains of V. cholerae with clinically significant resistance to tetracycline should be encountered.",
author = "Pierce, {N. F.} and Banwell, {J. G.} and Mitra, {R. C.} and Caranasos, {G. J.} and Keimowitz, {R. I.} and J. Thomas and A. Mondal",
note = "Funding Information: Methods and Materials The study was carried out in April to July 1967 and included 65 male patients over the age of 10 years who gave a history of {"}rice water{"} diarrhoea of less than 24 hours' duration without previous antibiotic treatment, and who showed evidence than 80 mm. Hg) when admitted(systolic blood pressure less of dehydration and hypotension to hospital. Data on 49 patients are presented, the remainder being excluded because of failure to identify Vibrio choleraeinthestool (14 patients) or because of technical errors in performance of the study (two patients). Immediately on admission the patient was weighed and placed on a metabolic bed. A brief physical examination was made, a femoral artery blood specimen obtained, and intra- venous fluid replacement promptlystarted. The intravenous fluid used contained Na 154 mEq/l., C1 103 mEq/l., and lactate * From the Johns Hopkins University Center for Medical Research and Training, the Infectious Diseases Hospital and the School ofTropical Medicine, Calcutta, India. This study was supported by research grants 5x4317, AI-07628-01, and 5RO7TW00141-07CIC from the United States National Institutes",
year = "1968",
month = aug,
day = "3",
doi = "10.1136/bmj.3.5613.277",
language = "English (US)",
volume = "3",
pages = "277--280",
journal = "British medical journal",
issn = "0007-1447",
publisher = "BMJ Publishing Group",
number = "5613",
}