@article{b146bfdb7b1a4aaf99b80c58200b0b17,
title = "Control of heparin therapy in open heart surgery",
abstract = "The widespread use of heparin in heart surgery has introduced the need for accurate tests to evaluate the blood clotting mechanism. In this study three such methods are compared: the Lee White clotting time, the activated plasma partial thromboplastin time (APTT), and the blood activated recalcification time (BART). The BART was found to be a valuable adjunct in the management of heparinized patients. With this test, it is possible to control more accurately the degree of heparinization and to determine more precisely the amount of protamine that will be required. Results of the BART can be obtained quickly and are reproducible.",
author = "M. Jaberi and Bell, {W. R.} and Benson, {D. W.}",
note = "Funding Information: Supported by NIH SCOR grant HL52338-05, the Nora Eccles Treadwell Foundation, and the Richard A. and Nora Eccles Harrison Fund for Cardiovascular Research. Reprint requests: Marc S. Fuller, PhD, University of Utah, CVRTI, 95 South 2000 East, Salt Lake City, UT 84112-5000; e-mail: marc.fuller@m.cc.utah,edu Copyright 9 2000 by Chttrchill Livingstone | 0022-0736/00/3302-0008510.00/0 doi: I 0,1054/xe.2000.6540 many years. The work of Han et al. (1) showed increased vulnerability to ventricular fibrillation arising from increased dispersion of refractoriness. Kubota et al. (2) showed increased vulnerability arising from increased dispersion of repolarization caused by localized warming. More recently, the studies of Antzelevitch et al. (3), Lukas and Ant-zelevitch (4), and Chinushi et al. (5) have shown the role that heterogeneity of repolarization plays in arrhythmogenesis. A series of simulation studies by Abildsk0v and Lux (6-9) documented the probabilistic nature of arrhythmia susceptibility and its dependence on local repolarization disparity. From",
year = "1974",
doi = "10.1016/s0022-5223(19)39768-5",
language = "English (US)",
volume = "67",
pages = "133--141",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "1",
}