Abstract— The inhibition of choline acetyltransferase by acetylcholine in vitro occurs at a concentration of 10 mm and increases progressively to 45 per cent at a concentration of 100 mm. The inhibition is competitive for choline and noncompetitive for acetyl‐CoA. It is suggested that the synthesis of acetylcholine may be controlled by its accumulation in synaptic vesicles.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Neurochemistry|
|State||Published - Jul 1969|
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience