Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep

Jason P. Kirkness, Alan R. Schwartz, Hartmut Schneider, Naresh M. Punjabi, Joseph J. Maly, Alison M. Laffan, Brian M. McGinley, Thomas Magnuson, Michael Schweitzer, Philip L. Smith, Susheel P. Patil

Research output: Contribution to journalArticlepeer-review

152 Scopus citations


Male sex, obesity, and age are risk factors for obstructive sleep apnea, although the mechanisms by which these factors increase sleep apnea susceptibility are not entirely understood. This study examined the interrelationships between sleep apnea risk factors, upper airway mechanics, and sleep apnea susceptibility. In 164 (86 men, 78 women) participants with and without sleep apnea, upper airway pressure-flow relationships were characterized to determine their mechanical properties [pharyngeal critical pressure under hypotonic conditions (passive Pcrit)] during non-rapid eye movement sleep. In multiple linear regression analyses, the effects of body mass index and age on passive Pcrit were determined in each sex. A subset of men and women matched by body mass index, age, and disease severity was used to determine the sex effect on passive Pcrit. The passive Pcrit was 1.9 cmH2O [95% confidence interval (CI): 0.1-3.6 cmH2O] lower in women than men after matching for body mass index, age, and disease severity. The relationship between passive Pcrit and sleep apnea status and severity was examined. Sleep apnea was largely absent in those individuals with a passive Pcrit less than -5 cmH2O and increased markedly in severity when passive Pcrit rose above -5 cmH 2O. Passive Pcrit had a predictive power of 0.73 (95% CI: 0.65- 0.82) in predicting sleep apnea status. Upper airway mechanics are differentially controlled by sex, obesity, and age, and partly mediate the relationship between these sleep apnea risk factors and obstructive sleep apnea.

Original languageEnglish (US)
Pages (from-to)1618-1624
Number of pages7
JournalJournal of applied physiology
Issue number6
StatePublished - Jun 2008


  • Obstructive sleep apnea
  • Pharynx
  • Physiopathology

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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