TY - JOUR
T1 - Contrast agent-enhanced, free-breathing, three-dimensional coronary magnetic resonance angiography
AU - Stuber, Matthias
AU - Botnar, René M.
AU - Danias, Peter G.
AU - McConnell, Michael V.
AU - Kissinger, Kraig V.
AU - Yucel, E. Kent
AU - Manning, Warren J.
PY - 1999/11
Y1 - 1999/11
N2 - For free-breathing, high-resolution, three-dimensional coronary magnetic resonance angiography (MRA), the use of intravascular contrast agents may be helpful for contrast enhancement between coronary blood and myocardium. In six patients, 0.1 mmol/kg of the intravascular contrast agent MS- 325/AngioMARK(TM) was given intravenously followed by double-oblique, free- breathing, three-dimensional inversion-recovery coronary MRA with real-time navigator gating and motion correction. Contrast-enhanced, three-dimensional coronary MRA images were compared with images obtained with a T2 prepulse (T2Prep) without exogenous contrast. The contrast-enhanced images demonstrated a 69% improvement in the contrast-to-noise ratio (6.6 ± 1.1 vs. 11.1 ± 2.5; P < 0.01) compared with the T2Prep approach. By using the intravascular agent, extensive portions (> 80 mm) of the native left and right coronary system could be displayed consistently with sub-millimeter in- plane resolution. The intravascular contrast agent, MS-325/AngioMARK(TM), leads to a considerable enhancement of the blood/muscle contrast for coronary MRA compared with T2Prep techniques. The clinical value of the agent remains to be defined in a larger patient series.
AB - For free-breathing, high-resolution, three-dimensional coronary magnetic resonance angiography (MRA), the use of intravascular contrast agents may be helpful for contrast enhancement between coronary blood and myocardium. In six patients, 0.1 mmol/kg of the intravascular contrast agent MS- 325/AngioMARK(TM) was given intravenously followed by double-oblique, free- breathing, three-dimensional inversion-recovery coronary MRA with real-time navigator gating and motion correction. Contrast-enhanced, three-dimensional coronary MRA images were compared with images obtained with a T2 prepulse (T2Prep) without exogenous contrast. The contrast-enhanced images demonstrated a 69% improvement in the contrast-to-noise ratio (6.6 ± 1.1 vs. 11.1 ± 2.5; P < 0.01) compared with the T2Prep approach. By using the intravascular agent, extensive portions (> 80 mm) of the native left and right coronary system could be displayed consistently with sub-millimeter in- plane resolution. The intravascular contrast agent, MS-325/AngioMARK(TM), leads to a considerable enhancement of the blood/muscle contrast for coronary MRA compared with T2Prep techniques. The clinical value of the agent remains to be defined in a larger patient series.
KW - Coronary magnetic resonance angiography
KW - High-resolution imaging
KW - Intravascular contrast agent
KW - Navigators
KW - Three-dimensional imaging
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U2 - 10.1002/(SICI)1522-2586(199911)10:5<790::AID-JMRI25>3.0.CO;2-I
DO - 10.1002/(SICI)1522-2586(199911)10:5<790::AID-JMRI25>3.0.CO;2-I
M3 - Article
C2 - 10548790
AN - SCOPUS:0032755672
SN - 1053-1807
VL - 10
SP - 790
EP - 799
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -