Contrast agent-enhanced, free-breathing, three-dimensional coronary magnetic resonance angiography

Matthias Stuber, René M. Botnar, Peter G. Danias, Michael V. McConnell, Kraig V. Kissinger, E. Kent Yucel, Warren J. Manning

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


For free-breathing, high-resolution, three-dimensional coronary magnetic resonance angiography (MRA), the use of intravascular contrast agents may be helpful for contrast enhancement between coronary blood and myocardium. In six patients, 0.1 mmol/kg of the intravascular contrast agent MS- 325/AngioMARK(TM) was given intravenously followed by double-oblique, free- breathing, three-dimensional inversion-recovery coronary MRA with real-time navigator gating and motion correction. Contrast-enhanced, three-dimensional coronary MRA images were compared with images obtained with a T2 prepulse (T2Prep) without exogenous contrast. The contrast-enhanced images demonstrated a 69% improvement in the contrast-to-noise ratio (6.6 ± 1.1 vs. 11.1 ± 2.5; P < 0.01) compared with the T2Prep approach. By using the intravascular agent, extensive portions (> 80 mm) of the native left and right coronary system could be displayed consistently with sub-millimeter in- plane resolution. The intravascular contrast agent, MS-325/AngioMARK(TM), leads to a considerable enhancement of the blood/muscle contrast for coronary MRA compared with T2Prep techniques. The clinical value of the agent remains to be defined in a larger patient series.

Original languageEnglish (US)
Pages (from-to)790-799
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - Nov 1999
Externally publishedYes


  • Coronary magnetic resonance angiography
  • High-resolution imaging
  • Intravascular contrast agent
  • Navigators
  • Three-dimensional imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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