Contraction and blood flow patterns in the left ventricle during abnormal electrical activation

Frits W. Prinzen; Theo Arts; Elliot R. McVeigh; William C. Hunter; Robert S. Reneman

Contraction and blood flow patterns in the left ventricle during abnormal electrical activation

Frits W. Prinzen, Theo Arts, Elliot R. McVeigh, William C. Hunter, Robert S. Reneman

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We investigated regional blood flow and contraction patterns during abnormal, asynchronous electrical activation of the left ventricle (LV), as induced by ventricular pacing in anesthetized open-chest dogs. 2D deformation of the anterior left ventricular (LV) epicardium was determined with optical markers and, in other experiments, 3D deformation of the entire LV wall using tagged Magnetic Resonance Imaging (MRI). Regional blood flow was determined with radioactive microspheres. Ventricular pacing caused characteristic patterns of systolic fiber shortening, being essentially zero in early and more than doubled in late activated regions. Myocardial blood flow was also (approximately 20%) lower in early and (approximately 35%) higher in late activated regions, as compared to normal activation. It is concluded that during asynchronous activation regional differences in contraction pattern cause differences in oxygen demand which, through autoregulation, lead to differences in blood flow.

Original language	English (US)
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publisher	IEEE
Pages	1336-1337
Number of pages	2
Volume	3
State	Published - 1996
Externally published	Yes
Event	Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth Duration: Oct 31 1996 → Nov 3 1996

Other

Other	Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
City	Amsterdam, Neth
Period	10/31/96 → 11/3/96

ASJC Scopus subject areas

Bioengineering

Cite this

Contraction and blood flow patterns in the left ventricle during abnormal electrical activation. / Prinzen, Frits W.; Arts, Theo; McVeigh, Elliot R. et al.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 3 IEEE, 1996. p. 1336-1337.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Prinzen, FW, Arts, T, McVeigh, ER, Hunter, WC & Reneman, RS 1996, Contraction and blood flow patterns in the left ventricle during abnormal electrical activation. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 3, IEEE, pp. 1336-1337, Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5), Amsterdam, Neth, 10/31/96.

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abstract = "We investigated regional blood flow and contraction patterns during abnormal, asynchronous electrical activation of the left ventricle (LV), as induced by ventricular pacing in anesthetized open-chest dogs. 2D deformation of the anterior left ventricular (LV) epicardium was determined with optical markers and, in other experiments, 3D deformation of the entire LV wall using tagged Magnetic Resonance Imaging (MRI). Regional blood flow was determined with radioactive microspheres. Ventricular pacing caused characteristic patterns of systolic fiber shortening, being essentially zero in early and more than doubled in late activated regions. Myocardial blood flow was also (approximately 20%) lower in early and (approximately 35%) higher in late activated regions, as compared to normal activation. It is concluded that during asynchronous activation regional differences in contraction pattern cause differences in oxygen demand which, through autoregulation, lead to differences in blood flow.",

author = "Prinzen, {Frits W.} and Theo Arts and McVeigh, {Elliot R.} and Hunter, {William C.} and Reneman, {Robert S.}",

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pages = "1336--1337",

booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

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note = "Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) ; Conference date: 31-10-1996 Through 03-11-1996",

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T1 - Contraction and blood flow patterns in the left ventricle during abnormal electrical activation

AU - Prinzen, Frits W.

AU - Arts, Theo

AU - McVeigh, Elliot R.

AU - Hunter, William C.

AU - Reneman, Robert S.

PY - 1996

Y1 - 1996

N2 - We investigated regional blood flow and contraction patterns during abnormal, asynchronous electrical activation of the left ventricle (LV), as induced by ventricular pacing in anesthetized open-chest dogs. 2D deformation of the anterior left ventricular (LV) epicardium was determined with optical markers and, in other experiments, 3D deformation of the entire LV wall using tagged Magnetic Resonance Imaging (MRI). Regional blood flow was determined with radioactive microspheres. Ventricular pacing caused characteristic patterns of systolic fiber shortening, being essentially zero in early and more than doubled in late activated regions. Myocardial blood flow was also (approximately 20%) lower in early and (approximately 35%) higher in late activated regions, as compared to normal activation. It is concluded that during asynchronous activation regional differences in contraction pattern cause differences in oxygen demand which, through autoregulation, lead to differences in blood flow.

AB - We investigated regional blood flow and contraction patterns during abnormal, asynchronous electrical activation of the left ventricle (LV), as induced by ventricular pacing in anesthetized open-chest dogs. 2D deformation of the anterior left ventricular (LV) epicardium was determined with optical markers and, in other experiments, 3D deformation of the entire LV wall using tagged Magnetic Resonance Imaging (MRI). Regional blood flow was determined with radioactive microspheres. Ventricular pacing caused characteristic patterns of systolic fiber shortening, being essentially zero in early and more than doubled in late activated regions. Myocardial blood flow was also (approximately 20%) lower in early and (approximately 35%) higher in late activated regions, as compared to normal activation. It is concluded that during asynchronous activation regional differences in contraction pattern cause differences in oxygen demand which, through autoregulation, lead to differences in blood flow.

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Y2 - 31 October 1996 through 3 November 1996

ER -

Contraction and blood flow patterns in the left ventricle during abnormal electrical activation

Abstract

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ASJC Scopus subject areas

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