Contactless fluorescence imaging with a CMOS image sensor

Andreas G. Andreou; Zhaonian Zhang; Recep Özgün; Edward T. Choi; Zaven K. Kalayjian; Miriam A. Marwick; Jennifer Blain Christen; Leslie Tung

doi:10.1109/ISCAS.2011.5938072

Contactless fluorescence imaging with a CMOS image sensor

Andreas G. Andreou, Zhaonian Zhang, Recep Özgün, Edward T. Choi, Zaven K. Kalayjian, Miriam A. Marwick, Jennifer Blain Christen, Leslie Tung

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

In this work, we utilize a CMOS active pixel sensor in a fluorescence imaging setup. The ability to sense small light intensity changes on top of a large baseline with spatial resolution at the subcellular scale is required in fluorescence imaging. The CMOS imager presented in [1] is perfect for this application with the ability to resolve fine features coupled with high dynamic range. By using a custom imager with a relay lens we are able to realize a dramatic decrease in device size, cost and complexity of the whole system.

Original language	English (US)
Title of host publication	2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011
Pages	2341-2344
Number of pages	4
DOIs	https://doi.org/10.1109/ISCAS.2011.5938072
State	Published - 2011
Event	2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011 - Rio de Janeiro, Brazil Duration: May 15 2011 → May 18 2011

Publication series

Name	Proceedings - IEEE International Symposium on Circuits and Systems
ISSN (Print)	0271-4310

Other

Other	2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011
Country/Territory	Brazil
City	Rio de Janeiro
Period	5/15/11 → 5/18/11

ASJC Scopus subject areas

Electrical and Electronic Engineering

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10.1109/ISCAS.2011.5938072

Cite this

Andreou, A. G., Zhang, Z., Özgün, R., Choi, E. T., Kalayjian, Z. K., Marwick, M. A., Blain Christen, J., & Tung, L. (2011). Contactless fluorescence imaging with a CMOS image sensor. In 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011 (pp. 2341-2344). Article 5938072 (Proceedings - IEEE International Symposium on Circuits and Systems). https://doi.org/10.1109/ISCAS.2011.5938072

Contactless fluorescence imaging with a CMOS image sensor. / Andreou, Andreas G.; Zhang, Zhaonian; Özgün, Recep et al.
2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011. 2011. p. 2341-2344 5938072 (Proceedings - IEEE International Symposium on Circuits and Systems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Andreou, AG, Zhang, Z, Özgün, R, Choi, ET, Kalayjian, ZK, Marwick, MA, Blain Christen, J & Tung, L 2011, Contactless fluorescence imaging with a CMOS image sensor. in 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011., 5938072, Proceedings - IEEE International Symposium on Circuits and Systems, pp. 2341-2344, 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011, Rio de Janeiro, Brazil, 5/15/11. https://doi.org/10.1109/ISCAS.2011.5938072

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abstract = "In this work, we utilize a CMOS active pixel sensor in a fluorescence imaging setup. The ability to sense small light intensity changes on top of a large baseline with spatial resolution at the subcellular scale is required in fluorescence imaging. The CMOS imager presented in [1] is perfect for this application with the ability to resolve fine features coupled with high dynamic range. By using a custom imager with a relay lens we are able to realize a dramatic decrease in device size, cost and complexity of the whole system.",

author = "Andreou, {Andreas G.} and Zhaonian Zhang and Recep {\"O}zg{\"u}n and Choi, {Edward T.} and Kalayjian, {Zaven K.} and Marwick, {Miriam A.} and {Blain Christen}, Jennifer and Leslie Tung",

year = "2011",

doi = "10.1109/ISCAS.2011.5938072",

language = "English (US)",

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AU - Marwick, Miriam A.

AU - Blain Christen, Jennifer

AU - Tung, Leslie

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AB - In this work, we utilize a CMOS active pixel sensor in a fluorescence imaging setup. The ability to sense small light intensity changes on top of a large baseline with spatial resolution at the subcellular scale is required in fluorescence imaging. The CMOS imager presented in [1] is perfect for this application with the ability to resolve fine features coupled with high dynamic range. By using a custom imager with a relay lens we are able to realize a dramatic decrease in device size, cost and complexity of the whole system.

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Y2 - 15 May 2011 through 18 May 2011

ER -

Contactless fluorescence imaging with a CMOS image sensor

Abstract

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ASJC Scopus subject areas

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