Construction of optically pure tryptophans from serine derived aziridine-2-carboxylates

Kazuo Sato, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


The possibility of preparing optically pure tryptophan derivatives from various substituted indoles and (2R)- or (2S)-2-aziridinecarboxylates has been examined. Zinc triflate was found to be the only Lewis acid capable of bringing about this reaction in moderate yields.

Original languageEnglish (US)
Pages (from-to)4073-4076
Number of pages4
JournalTetrahedron Letters
Issue number31
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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