Constructing an organ: The Drosophila salivary gland as a model for tube formation

Elliott W. Abrams, Melissa S. Vining, Deborah J. Andrew

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Tubes are required in metazoans to transport the liquids and gases that sustain life. The conservation of molecules and mechanisms involved in tube formation suggests that what we learn by studying simple systems will apply to related processes in higher animals. Studies over the past 10 years have revealed the molecules that specify cell fate in Drosophila salivary gland and the cellular events that mediate tube morphogenesis. Here, we discuss how anterior-posterior and dorsal-ventral patterning information specifies both the position of salivary-gland primordia and how many cells they contain. We examine the transformation of a polarized epithelial sheet into an elongated, unbranched tube, and the intrinsic and extrinsic factors that influence the final position of the salivary gland.

Original languageEnglish (US)
Pages (from-to)247-254
Number of pages8
JournalTrends in Cell Biology
Issue number5
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Cell Biology


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