TY - GEN
T1 - Constant-current adjustable-waveform micro Stimulator for an implantable hybrid neural prosthesis
AU - Hassell, Travis J.
AU - Jedlicka, Sabrina S.
AU - Rickus, Jenna L.
AU - Irazoqui, Pedro P.
PY - 2007
Y1 - 2007
N2 - Microstimulation of neural tissue has become a widely-used technique for controlling neuronal responses with local electric fields as well as a therapeutic intervention for nervous system disorders such as epilepsy and Parkinson's disease. Of those afflicted by neurological diseases, many are or become tolerant to existing pharmaceuticals and are left with little recourse. Little is known about the necessary design criteria or efficacy of a hybrid neural prosthesis. Assessment of the potential clinical value of a hybrid electro-chemical neural prosthesis was performed through in vitro verification using a prototype microstimulator and P19 cell cultures. We constructed a printed circuit board (PCB) microstimulator as a prototype of a CMOS microstimulator ASIC that was subsequently fabricated in the IBM 7RF 0.18 um process. Measured results for the prototype are described in this work. An output impedance of 237 kΩ, voltage compliance of 11.3 V, and a linear constant-current output up to +/-600 uA make this microstimulator system a viable option for an implantable hybrid neural prosthesis. Hybrid prostheses could uniquely affect neural modulation with linear glutamate release at physiological amplitudes and frequencies.
AB - Microstimulation of neural tissue has become a widely-used technique for controlling neuronal responses with local electric fields as well as a therapeutic intervention for nervous system disorders such as epilepsy and Parkinson's disease. Of those afflicted by neurological diseases, many are or become tolerant to existing pharmaceuticals and are left with little recourse. Little is known about the necessary design criteria or efficacy of a hybrid neural prosthesis. Assessment of the potential clinical value of a hybrid electro-chemical neural prosthesis was performed through in vitro verification using a prototype microstimulator and P19 cell cultures. We constructed a printed circuit board (PCB) microstimulator as a prototype of a CMOS microstimulator ASIC that was subsequently fabricated in the IBM 7RF 0.18 um process. Measured results for the prototype are described in this work. An output impedance of 237 kΩ, voltage compliance of 11.3 V, and a linear constant-current output up to +/-600 uA make this microstimulator system a viable option for an implantable hybrid neural prosthesis. Hybrid prostheses could uniquely affect neural modulation with linear glutamate release at physiological amplitudes and frequencies.
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U2 - 10.1109/IEMBS.2007.4352820
DO - 10.1109/IEMBS.2007.4352820
M3 - Conference contribution
C2 - 18002486
AN - SCOPUS:57649153141
SN - 1424407885
SN - 9781424407880
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 2436
EP - 2439
BT - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
T2 - 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Y2 - 23 August 2007 through 26 August 2007
ER -