Consistent subtype-specific anti-HIV type 1 T lymphocyte responses in Indian subjects recently infected with HIV type 1

Madhuri R. Thakar, Deepa Patke, Samir K. Lakhashe, Leena Bhonge, Sangeeta V. Kulkarni, Srikanth P. Tripathy, Nikhil Gupte, Ronald Brookmeyer, Thomas C. Quinn, Ramesh S. Paranjape, Robert C. Bollinger

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Anti-HIV-1-specific T cell responses in early HIV-1 infection have been found to be important in deciding the course of disease progression. But there are few data concerning nonsubtype B HIV infection. HIV-1 subtype C is the most prevalent subtype in India. HIV-1 Gag-specific T cell responses in 12 Indian subjects with recent HIV-1 infection were characterized by an ELISpot assay at two consecutive visits and their correlation with plasma viral load and CD4+ T lymphocyte counts was studied. Ten of the 12 subjects demonstrated T cell responses to either one or both Gag B and C pepfides, on at least one visit. Five of 10 responders showed a consistent response (response at both visits): 4 exhibited a Gag C-specific consistent response and 1 showed a consistent response to Gag B. The remaining five patients, showing response at only one of the two visits, were considered inconsistent responders. None of the individuals showed a consistent response to both B and C Gag peptides. Marginally significant correlation was observed between consistency of the response and lower plasma viral load (p = 0.062). The subtype-specific Gag C response was also found to be correlated with lower viral load as compared with the response to Gag B (r = -0.336, p = 0.054 for subtype C and r = -0.234, p = 0.13 for subtype B). The data suggest that the patients exhibiting consistent subtype-specific responses to HIV-1 Gag might have better control of viral replication in early HIV infection.

Original languageEnglish (US)
Pages (from-to)1389-1393
Number of pages5
JournalAIDS research and human retroviruses
Issue number18
StatePublished - 2002

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases


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