TY - JOUR
T1 - Consistency of isochromosome 7q and trisomy 8 in hepatosplenic γδ T- cell lymphoma
T2 - Detection by fluorescence in situ hybridization of a splenic touch-preparation from a pediatric patient
AU - Coventry, Susan
AU - Punnett, Hope H.
AU - Tomczak, Ewa Z.
AU - Casher, Danielle
AU - Koehler, Maria
AU - Borowitz, Michael J.
AU - Griffin, Constance A.
AU - De Chadarévian, Jean Pierre
PY - 1999/9
Y1 - 1999/9
N2 - Hepatosplenic gamma-delta (γδ) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch- preparation of the spleen.
AB - Hepatosplenic gamma-delta (γδ) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch- preparation of the spleen.
KW - Fever of unknown origin
KW - Hepatosplenic lymphoma
KW - Isochromosome 7q
KW - Trisomy 8
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U2 - 10.1007/s100249900152
DO - 10.1007/s100249900152
M3 - Article
C2 - 10441626
AN - SCOPUS:0032816228
SN - 1093-5266
VL - 2
SP - 478
EP - 483
JO - Pediatric and Developmental Pathology
JF - Pediatric and Developmental Pathology
IS - 5
ER -