TY - JOUR
T1 - Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF
AU - Esumi, Noriko
AU - Budarf, Marcia
AU - Ciccarelli, Lawrence
AU - Sellinger, Beatrice
AU - Kozak, Christine A.
AU - Wistow, Graeme
N1 - Funding Information:
S. F. J. Le Grice is supported by grants AI 31147 and GM 46623 from the National Institutes of Health. S. J. Benkovici s supported by grant GM13306 from the National Institutes of Health, C. E. Cameron is supported by fellowship 41 09076 from the National Institutes of Health. A portion of the work presented here was also supported by a NATO collaborative research grant (CRG 900.471) to S. F. J. Le Grice. The technical assistance of K. J. Howard in preparation of p66/p51 HIV-1 RT variants is gratefully acknowledged.
Funding Information:
We thank B6n6dicte Purcell and Stephen Oliver for the plasmid YCR14C. This work was supported by grants from the USPHS (GM25508 and GM47281) and California TRDRP 3RT-0190.
PY - 1998
Y1 - 1998
N2 - Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure. Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely linked on human Chromosome (Chr) 22 and mouse Chr 10.
AB - Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure. Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely linked on human Chromosome (Chr) 22 and mouse Chr 10.
UR - https://www.scopus.com/pages/publications/0031660858
UR - https://www.scopus.com/pages/publications/0031660858#tab=citedBy
U2 - 10.1007/s003359900858
DO - 10.1007/s003359900858
M3 - Article
C2 - 9716662
AN - SCOPUS:0031660858
SN - 0938-8990
VL - 9
SP - 753
EP - 757
JO - Mammalian Genome
JF - Mammalian Genome
IS - 9
ER -