Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF

Noriko Esumi, Marcia Budarf, Lawrence Ciccarelli, Beatrice Sellinger, Christine A. Kozak, Graeme Wistow

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure. Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely linked on human Chromosome (Chr) 22 and mouse Chr 10.

Original languageEnglish (US)
Pages (from-to)753-757
Number of pages5
JournalMammalian Genome
Issue number9
StatePublished - 1998

ASJC Scopus subject areas

  • Genetics


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