Conservation of the mammalian RNA polymerase II largest-subunit C-terminal domain

Emily Barron-Casella, Jeffry L. Corden

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We have isolated and sequenced a portion of the gene encoding the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II from three mammals. These mammalian sequences include one rodent and two primate CTDs. Comparisons of the new sequences to mouse and Chinese hamster show a high degree of conservation among the mammalian CTDs. Due to synonymous codon usage, the nucleotide differences between hamster, rat, ape, and human result in no amino acid changes. The amino acid sequence for the mouse CTD appears to have one different amino acid when compared to the other four sequences. Therefore, except for the one variation in mouse, all of the known mammalian CTDs have identical amino acid sequences. This is in marked contrast to the situation among more divergent species. The present study suggests that there is a strong evolutionary pressure to maintain the primary structure of the mammalian CTD.

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalJournal of Molecular Evolution
Issue number5
StatePublished - Nov 1992


  • Carboxy-terminal domain
  • Largest subunit
  • Mammalian
  • RNA polymerase II

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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