Congenital diarrhea with intestinal inflammation and epithelial immaturity

Marjorie E. Kanof, Naomi E. Ranee, Stanley R. Hamilton, Gordon D. Luk, Alan M. Lake

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We report an interesting case of congenital in, flammatory bowel disease and intestinal epithelial immaturity that presented as secretory diarrhea. No infectious, metabolic, or anatomical basis for these findings was identified. As differentiated from previous reports of neonatal enteropathies, this infant demonstrated involvement of both the small and large intestine with histopathologic findings of acute and chronic inflammation, extensive submucosal fibrosis, and “flat” small intestine mucosa. In addition, this patient had a polyamine deficiency (a primary or secondary phenomenon), which may have contributed to delayed epithelial maturation. These findings suggest that the inflammatory bowel disease and altered epithelial maturation contributed to a fatal intractable diarrhea.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Issue number1
StatePublished - Jan 1987
Externally publishedYes


  • Inflammatory bowel disease
  • Intestinal epithelial immaturity
  • Intractable diarrhea
  • Polyamines

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology


Dive into the research topics of 'Congenital diarrhea with intestinal inflammation and epithelial immaturity'. Together they form a unique fingerprint.

Cite this