Congenital and acquired abnormalities of the pediatric brain

William S. Ball, Thierry A G M Huisman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The normal development of the brain is highly complex and involves multiple, tightly linked, interacting, and well-defined genetically programmed processes. Any interference with the normal development may have a significant impact on quality of life. Typically, developmental abnormalities of the brain are classified as congenital versus acquired. This classification may seem straightforward: for example, a rhombencephalosynapsis (congenital fusion of cerebellar hemispheres) is a classic congenital malformation, whereas an intrauterine focal thromboembolic cerebral infarction is a typical acquired lesion. There is, however, a significant overlap. Focal hypoperfusion of a part of the developing brain may interfere with normal neuronal migration, resulting in a migrational abnormality or even in more severe brain abnormalities. In this situation, an acute event has interfered with normal development, resulting in a developmental disorder of the brain. In congenital abnormalities, the malformation may result from a genetically encoded aberrant brain development.

Original languageEnglish (US)
Title of host publicationDiseases of the Brain, Head and Neck, Spine 2012-2015: Diagnostic Imaging and Interventional Techniques
PublisherSpringer-Verlag Milan
Number of pages15
ISBN (Print)9788847026285, 9788847026278
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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