Confirmation of Cocaine in Human Saliva after Intravenous Use

Loren K. Thompson, David Yousefnejad, Karen Kumor, Michael Sherer, Edward J. Cone

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The presence of cocaine was confirmed in the saliva of two male human subjects who had received intravenous doses of cocaine. For one subject, the saliva:plasma concentration ratios varied from 2.96 to 0.5 over time following drug administration. Correlations of saliva to plasma cocaine levels were highly significant (p ` 0.001) across doses of 15, 20, and 40 mg of intravenously administered cocaine. These findings are important in that they allow monitoring blood levels of cocaine after intravenous infusion in a non-invasive manner, and could form the basis for development of a non-invasive screen for active cocaine levels in saliva.

Original languageEnglish (US)
Pages (from-to)36-38
Number of pages3
JournalJournal of analytical toxicology
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

Fingerprint

Dive into the research topics of 'Confirmation of Cocaine in Human Saliva after Intravenous Use'. Together they form a unique fingerprint.

Cite this