Confirmation of Cocaine in Human Saliva after Intravenous Use

Loren K. Thompson, David Yousefnejad, Karen Kumor, Michael Sherer, Edward J. Cone

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


The presence of cocaine was confirmed in the saliva of two male human subjects who had received intravenous doses of cocaine. For one subject, the saliva:plasma concentration ratios varied from 2.96 to 0.5 over time following drug administration. Correlations of saliva to plasma cocaine levels were highly significant (p ` 0.001) across doses of 15, 20, and 40 mg of intravenously administered cocaine. These findings are important in that they allow monitoring blood levels of cocaine after intravenous infusion in a non-invasive manner, and could form the basis for development of a non-invasive screen for active cocaine levels in saliva.

Original languageEnglish (US)
Pages (from-to)36-38
Number of pages3
JournalJournal of analytical toxicology
Issue number1
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety


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