Conference report on contractures in musculoskeletal and neurological conditions

Glen H. Nuckolls, Kathi Kinnett, Sudarshan Dayanidhi, Andrea A. Domenighetti, Tina Duong, Yetrib Hathout, Michael W. Lawlor, Sabrina S.M. Lee, S. Peter Magnusson, Craig M. McDonald, Elizabeth M. McNally, Natalie F. Miller, Bradley B. Olwin, Preeti Raghavan, Thomas J. Roberts, Seward B. Rutkove, John F. Sarwark, Claudia R. Senesac, Leslie F. Vogel, Glenn A. WalterRebecca J. Willcocks, William Z. Rymer, Richard L. Lieber

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19–20, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalMuscle and Nerve
Issue number6
StatePublished - Jun 1 2020
Externally publishedYes


  • Duchenne muscular dystrophy
  • cerebral palsy
  • contracture
  • muscle
  • stroke

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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