@article{29c7d11648434aabb07c0a0891da4c75,
title = "Conference report on contractures in musculoskeletal and neurological conditions",
abstract = "Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19–20, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development.",
keywords = "Duchenne muscular dystrophy, cerebral palsy, contracture, muscle, stroke",
author = "Nuckolls, {Glen H.} and Kathi Kinnett and Sudarshan Dayanidhi and Domenighetti, {Andrea A.} and Tina Duong and Yetrib Hathout and Lawlor, {Michael W.} and Lee, {Sabrina S.M.} and Magnusson, {S. Peter} and McDonald, {Craig M.} and McNally, {Elizabeth M.} and Miller, {Natalie F.} and Olwin, {Bradley B.} and Preeti Raghavan and Roberts, {Thomas J.} and Rutkove, {Seward B.} and Sarwark, {John F.} and Senesac, {Claudia R.} and Vogel, {Leslie F.} and Walter, {Glenn A.} and Willcocks, {Rebecca J.} and Rymer, {William Z.} and Lieber, {Richard L.}",
note = "Funding Information: The authors thank Thomas Cheever, PhD (NIAMS/NIH) and Ralph Nitkin, PhD (NICHD/NIH) for their efforts in planning the conference and contributing to this summary and Carsten B{\"o}nnemann, MD (NINDS/NIH) for insightful comments on this meeting summary. This workshop was supported by NICHD, NINDS, PPMD and SRAlab. This article summarizes the research findings presented and topics discussed at the meeting. Funding Information: This workshop was supported by National Institute of Child Health and Human Development, National Institute of Neurological Disorders and Stroke, Parent Project Muscular Dystrophy, and Shirley Ryan AbilityLab Funding information Funding Information: The authors thank Thomas Cheever, PhD (NIAMS/NIH) and Ralph Nitkin, PhD (NICHD/NIH) for their efforts in planning the conference and contributing to this summary and Carsten B{\"o}nnemann, MD (NINDS/NIH) for insightful comments on this meeting summary. This workshop was supported by NICHD, NINDS, PPMD and SRAlab. This article summarizes the research findings presented and topics discussed at the meeting. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals, Inc.",
year = "2020",
month = jun,
day = "1",
doi = "10.1002/mus.26845",
language = "English (US)",
volume = "61",
pages = "740--744",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "6",
}