Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group

Nicole T. Baumer, Mara L. Becker, George T. Capone, Kathleen Egan, Juan Fortea, Benjamin L. Handen, Elizabeth Head, James E. Hendrix, Ruth Y. Litovsky, Andre Strydom, Ignacio E. Tapia, Michael S. Rafii

Research output: Contribution to journalReview articlepeer-review

Abstract

The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). This new NIH funding mechanism offers new opportunities to expand and develop novel approaches in engaging and effectively enrolling a broader representation of clinical trials participants addressing current medical issues faced by individuals with DS. To address this opportunity, the NIH assembled leading clinicians, scientists, and representatives of advocacy groups to review existing methods and to identify those areas where new approaches are needed to engage and prepare DS populations for participation in clinical trial research. This paper summarizes the results of the Clinical Trial Readiness Working Group that was part of the INCLUDE Project Workshop: Planning a Virtual Down Syndrome Cohort Across the Lifespan Workshop held virtually September 23 and 24, 2019.

Original languageEnglish (US)
Article number22
JournalJournal of Neurodevelopmental Disorders
Volume14
Issue number1
DOIs
StatePublished - Dec 2022

Keywords

  • Clinical research
  • Clinical trials
  • Down syndrome
  • Intellectual disability
  • Recruitment
  • Research engagement

ASJC Scopus subject areas

  • Clinical Neurology
  • Cognitive Neuroscience
  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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