Concurrent angiomyolipoma and renal cell neoplasia: A study of 36 cases

Rafael E. Jimenez, John N. Eble, Victor E. Reuter, Jonathan I. Epstein, Andrew L. Folpe, Mariza De Peralta-Venturina, Pheroze Tamboli, I. David Ansell, David J. Grignon, Robert H. Young, Mahul B. Amin

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103 Scopus citations


Little is known about the association of angiomyolipoma and adult renal-cell neoplasia. We studied the clinicopathologic features of 36 patients with concurrent angiomyolipoma and renal-cell neoplasia from the consultation and surgical pathology files of nine institutions. HMB-45 immunoreactivity was analyzed in both neoplasms. Twenty-five sporadic cases of patients with angiomyolipoma and renal-cell neoplasia and 11 cases of patients with tuberous sclerosis, as defined by Gomez' criteria, had mean ages of 59 and 53 years, respectively, and female-male ratios of 2:1 and 5:1, respectively. The mean size of the angiomyolipomas was 1 cm in the sporadic cases and 3 cm in those patients with tuberous sclerosis (medians: 0.5 and 3 cm, respectively, P = .002). The mean sizes of the renal-cell neoplasms were 5 cm in sporadic cases and 6 cm in patients with tuberous sclerosis (medians: 4 and 5 cm, respectively; P = .88). In both clinical settings, angiomyolipoma was more commonly the incidental tumor. Clear-cell (conventional) renal-cell carcinoma was the most common renal-cell neoplasm in both groups of patients, accounting for approximately two thirds of the rumors. In patients with tuberous sclerosis, 27% of renal-cell neoplasms were oncocytomas, compared with 8% in sporadic cases (P = .15). Papillary neoplasia, chromophobe, and collecting-duct renal-cell carcinoma were found only in sporadic cases. All of the 22 renal-cell neoplasms studied were negative for HMB-45, whereas all 25 angiomyolipomas studied were positive.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalModern Pathology
Issue number3
StatePublished - 2001


  • Angiomyolipoma
  • Clear cell carcinoma
  • Collision neoplasms
  • Kidney
  • Oncocytoma
  • Renal cell carcinoma
  • Renal cell neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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