Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder

D. Behar; J. L. Rapoport; C. J. Berg; M. B. Denckla; L. Mann; C. Cox; P. Fedio; T. Zahn; M. G. Wolfman

doi:10.1176/ajp.141.3.363

Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder

D. Behar, J. L. Rapoport, C. J. Berg, M. B. Denckla, L. Mann, C. Cox, P. Fedio, T. Zahn, M. G. Wolfman

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233 Scopus citations

Abstract

The authors administered CAT scans and neuropsychological tests to 16 adolescents with obsessive-compulsive disorder (mean age ±SD=13.7 ± 1.6 years) and 16 matched controls. The patients had a mean ventricular-brain ratio (VBR) significantly higher than the controls' and showed spatial-perceptual deficits similar to those found in patients with frontal lobe lesions. Memory, reaction time, and decision time did not differ significantly from controls'. Neurodevelopmental examination of seven patients yielded a high frequency of age-inappropriate synkinesias and left hemibody signs. These results suggest CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement. However, the patients' neuropsychological test deficits and VBRs were not correlated.

Original language	English (US)
Pages (from-to)	363-369
Number of pages	7
Journal	American Journal of Psychiatry
Volume	141
Issue number	3
DOIs	https://doi.org/10.1176/ajp.141.3.363
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1176/ajp.141.3.363

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abstract = "The authors administered CAT scans and neuropsychological tests to 16 adolescents with obsessive-compulsive disorder (mean age ±SD=13.7 ± 1.6 years) and 16 matched controls. The patients had a mean ventricular-brain ratio (VBR) significantly higher than the controls' and showed spatial-perceptual deficits similar to those found in patients with frontal lobe lesions. Memory, reaction time, and decision time did not differ significantly from controls'. Neurodevelopmental examination of seven patients yielded a high frequency of age-inappropriate synkinesias and left hemibody signs. These results suggest CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement. However, the patients' neuropsychological test deficits and VBRs were not correlated.",

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AU - Behar, D.

AU - Rapoport, J. L.

AU - Berg, C. J.

AU - Denckla, M. B.

AU - Mann, L.

AU - Cox, C.

AU - Fedio, P.

AU - Zahn, T.

AU - Wolfman, M. G.

PY - 1984

Y1 - 1984

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AB - The authors administered CAT scans and neuropsychological tests to 16 adolescents with obsessive-compulsive disorder (mean age ±SD=13.7 ± 1.6 years) and 16 matched controls. The patients had a mean ventricular-brain ratio (VBR) significantly higher than the controls' and showed spatial-perceptual deficits similar to those found in patients with frontal lobe lesions. Memory, reaction time, and decision time did not differ significantly from controls'. Neurodevelopmental examination of seven patients yielded a high frequency of age-inappropriate synkinesias and left hemibody signs. These results suggest CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement. However, the patients' neuropsychological test deficits and VBRs were not correlated.

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Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder

Abstract

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