Computer generation of fibrillation in a 3-dimensional model of heart

Nitish V. Thakor, Lawrence N. Eisenman

Research output: Contribution to journalConference articlepeer-review


A three-dimensional (3-D) model of electrical propagation in the heart is presented. The model is constructed by discretizing a real dog heart into 1473 cubic elements with 3-mm sides. Each cellular element can be in one of five states: excitable, three relatively refractory, and unexcitable. In the excitable or relatively refractory states an element can propagate, with varying velocities, the electrical excitation in 3-D to its neighbors. Pacing this model results in normal action potentials and propagation, while extrastimulation results in fibrillation. The simulations show that fibrillation results from rapid re-excitation of cellular elements and dispersion refractory states in the cell population.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalComputers in cardiology
StatePublished - Sep 1 1988
EventComputers in Cardiology 1988 - Washington, DC, USA
Duration: Sep 25 1988Sep 28 1988

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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