TY - JOUR
T1 - Computer-Assisted Corneal Topography in Family Members of Patients With Keratoconus
AU - Rabinowitz, Yaron S.
AU - Garbus, Jenny
AU - McDonnell, Peter J.
PY - 1990/3
Y1 - 1990/3
N2 - In about 6% of patients with keratoconus, there is a history of familial disease. High keratometric astigmatism and mildly irregular mires observed by placidois disc have been suggested to represent variable forms of expression of a gene in family members of patients with keratoconus. We used a computerassisted digital videophotokeratoscope to map the corneas of 28 family members of 5 patients with keratoconus. Abnormalities observed in family members included central steepening, greater steepening of the cornea inferior to the apex, and substantial asymmetry in the central dioptric power between the two eyes of the same individual. These findings were similar to, but less severe than, those found in patients with keratoconus and may represent the variable expression of a gene contributing to the development of keratoconus. Pedigree analysis in these families suggests an autosomal dominant mode of inheritance.
AB - In about 6% of patients with keratoconus, there is a history of familial disease. High keratometric astigmatism and mildly irregular mires observed by placidois disc have been suggested to represent variable forms of expression of a gene in family members of patients with keratoconus. We used a computerassisted digital videophotokeratoscope to map the corneas of 28 family members of 5 patients with keratoconus. Abnormalities observed in family members included central steepening, greater steepening of the cornea inferior to the apex, and substantial asymmetry in the central dioptric power between the two eyes of the same individual. These findings were similar to, but less severe than, those found in patients with keratoconus and may represent the variable expression of a gene contributing to the development of keratoconus. Pedigree analysis in these families suggests an autosomal dominant mode of inheritance.
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U2 - 10.1001/archopht.1990.01070050063032
DO - 10.1001/archopht.1990.01070050063032
M3 - Article
C2 - 2310336
AN - SCOPUS:0025363515
SN - 0003-9950
VL - 108
SP - 365
EP - 371
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 3
ER -