Compressed sensing based intensity non-uniformity correction

Snehashis Roy, Aaron Carass, Jerry L. Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


We present a compressed sensing based approach to remove gain field from magnetic resonance (MR) images of the human brain. During image acquisition, the inhomogeneity present in the radio-frequency (RF) coil appears as shading artifact in the intensity image. The inhomogeneity poses problem in any automatic algorithm that uses intensity as a feature. It has been shown that at low field strength, the shading can be assumed to be a smooth field that is composed of low frequency components. Thus most inhomogeneity correction algorithms assume some kind of explicit smoothness criteria on the field. This sometimes limits the performance of the algorithms if the actual inhomogeneity is not smooth, which is the case at higher field strength. We describe a model-free, nonparametric patch-based approach that uses compressed sensing for the correction. We show that these features enable our algorithm to perform comparably with a current state of the art method N3 on images acquired at low field, while outperforming N3 when the image has non-smooth inhomogeneity, such as 7T images.

Original languageEnglish (US)
Title of host publication2011 8th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI'11
Number of pages4
StatePublished - 2011
Event2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 - Chicago, IL, United States
Duration: Mar 30 2011Apr 2 2011

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Other2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Country/TerritoryUnited States
CityChicago, IL


  • 7T
  • MRI
  • bias correction
  • bias field
  • intensity inhomogeneity
  • intensity non-uniformity

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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