@article{cb3b6a78eb1c447a9837ae6e6167b32d,
title = "Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers",
abstract = "The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.",
author = "Xiaohui Yan and Zhongyi Hu and Yi Feng and Xiaowen Hu and Jiao Yuan and Zhao, {Sihai D.} and Youyou Zhang and Lu Yang and Weiwei Shan and Qun He and Lingling Fan and Kandalaft, {Lana E.} and Tanyi, {Janos L.} and Chunsheng Li and Yuan, {Chao Xing} and Dongmei Zhang and Huiqing Yuan and Keqin Hua and Yiling Lu and Dionyssios Katsaros and Qihong Huang and Kathleen Montone and Yi Fan and George Coukos and Jeff Boyd and Sood, {Anil K.} and Timothy Rebbeck and Mills, {Gordon B.} and Dang, {Chi V.} and Lin Zhang",
note = "Funding Information: We thank the TCGA and CCLE project teams. This work was supported, in whole or in part, by the Basser Center for BRCA (L.Z.), the Harry Fields Professorship (L.Z.); the NIH (grants R01CA142776 to L.Z., R01CA190415 to L.Z., P50CA174523 to L.Z., P50CA083638 to J.B. and L.Z., R01CA148759 to Q.H., P50CA083639 to G.B.M., P50CA098258 to G.B.M., U24CA143883 to G.B.M., and P01CA099031 to G.B.M.), the Ovarian Cancer Research Fund (X.H.), the Foundation for Women{\textquoteright}s Cancer (X.H.), and the Breast Cancer Alliance (L.Z. and C.V.D.). D.Z. and L.Y. were supported by the China Scholarship Council. The Functional Proteomics RPPA Core is supported by NIH grant CA016672. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = oct,
day = "12",
doi = "10.1016/j.ccell.2015.09.006",
language = "English (US)",
volume = "28",
pages = "529--540",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}