Composite liver tumors: a radiologic-pathologic correlation

Megha Nayyar, David K. Imagawa, Temel Tirkes, Aram N. Demirjian, Roozbeh Houshyar, Kumar Sandrasegaran, Chaitali S. Nangia, Tara Seery, P. Bhargava, Joon I.i. Choi, Chandana Lall

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.

Original languageEnglish (US)
Pages (from-to)406-410
Number of pages5
JournalClinical and molecular hepatology
Issue number4
StatePublished - Dec 1 2014


  • Bi-phenotypic tumors
  • Cholangiocarcinoma
  • Computed tomography, Magnetic resonance imaging
  • Hepatoceullular carcinoma

ASJC Scopus subject areas

  • Hepatology
  • Molecular Biology


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