CompLications of Transfusion

M. B. Pagano, A. A.R. Tobian

Research output: Chapter in Book/Report/Conference proceedingChapter


Blood transfusion by replacing coagulation factors, platelets, and/or red blood cells, can be a Life-saving intervention for individuals with blood loss or impaired production. However, this practice is not without risks, and a myriad of adverse events, including noninfectious and infectious compLications, can occur during or following a blood transfusion. During the last 100 years, lessons learned about immunohematology, immune-mediated reactions, and transfusion-transmitted infections have led to the development of testing strategies and the design of cLinical practices that have made the use of blood products extremely safe. This article summarizes the history of transfusion medicine, describes the current knowledge about the pathophysiology of noninfectious transfusion reactions, provides epidemiologic data about infectious disease risks associated with transfusion, and describes the screening process of blood donation.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
StatePublished - Jan 1 2014


  • Acute lung injury
  • Allergic reactions
  • Anaphylaxis
  • Circulatory overload
  • Complement activation
  • Febrile nonhemolytic
  • Hemolysis
  • Hepatitis
  • HIV
  • Infection
  • Irradiation
  • Leukoreduction
  • Pathogen inactivation
  • Platelet additive solution
  • Transfusion reactions

ASJC Scopus subject areas

  • Medicine(all)


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