Complications of AlphaCor keratoprosthesis: A clinicopathologic report

Kakarla V. Chalam, Amit Chokshi, Swati Agarwal, Deepak P. Edward

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


PURPOSE: To describe the clinical and histopathologic features of intractable secondary glaucoma induced by AlphaCor keratoprosthesis. METHODS: An elderly woman with pseudoexfoliation glaucoma and pseudophakic bullous keratopathy in the right eye had graft failures after penetrating keratoplasty. Her best-corrected visual acuity at presentation was counting fingers in the right eye and 20/30 in the left eye. Examination showed severe corneal neovascularization. Chirila keratoprosthesis type II was implanted in 2 stages. Ten months later, the patient developed dense retrocorneal membrane, 360° occlusion of angles, intractable glaucoma, no light perception, and nasal stromal melting associated with partial extrusion of the keratoprosthesis. RESULTS: Histopathology revealed invasion of the porous material of the keratoprosthesis by reactive fibroblasts and multinucleated foreign-body giant cells. In the area of dehiscence, we noted thinning and lysis of the collagen fibers, infiltration of lymphocytes, and plasma cells with a sheet of fibroinflammatory tissue extending into the anterior chamber. CONCLUSIONS: Corneal stromal melting and retrocorneal prosthetic membrane formation after AlphaCor keratoprosthesis implantation led to intractable glaucoma and extrusion of the implant.

Original languageEnglish (US)
Pages (from-to)1258-1260
Number of pages3
Issue number10
StatePublished - Dec 2007
Externally publishedYes


  • AlphaCor keratoprosthesis
  • Complication
  • Graft failure
  • Histopathology
  • Penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology


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